TY - JOUR
T1 - Ganoderic acid TR, a new lanostanoid with 5α-reductase inhibitory activity from the fruiting body of Ganoderma lucidum
AU - Liu, Jie
AU - Shimizu, Kuniyoshi
AU - Kondo, Ryuichiro
PY - 2006
Y1 - 2006
N2 - By means of 5α-reductase inhibitory activity-guided fractionation, a new lanostanoid, 15α-hydroxy-3-oxolanosta- 7, 9(11), 24(E)-trien-26-oic acid, named as ganoderic acid TR, was isolated from the ethanol extract of the fruiting bodies of Ganoderma lucidum (Fr.) Karst (Ganodermataceae). The compound showed potent inhibitory activity with an IC50 of 8.5 μM. Modified Mosher's method established the S-configuration of the secondary hydroxyl group at C-15. In addition, a carboxyl group on the side chain of ganoderic acid TR is essential to elicit the inhibitory activity because of the considerably lower activity of its methyl ester.
AB - By means of 5α-reductase inhibitory activity-guided fractionation, a new lanostanoid, 15α-hydroxy-3-oxolanosta- 7, 9(11), 24(E)-trien-26-oic acid, named as ganoderic acid TR, was isolated from the ethanol extract of the fruiting bodies of Ganoderma lucidum (Fr.) Karst (Ganodermataceae). The compound showed potent inhibitory activity with an IC50 of 8.5 μM. Modified Mosher's method established the S-configuration of the secondary hydroxyl group at C-15. In addition, a carboxyl group on the side chain of ganoderic acid TR is essential to elicit the inhibitory activity because of the considerably lower activity of its methyl ester.
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U2 - 10.1177/1934578x0600100501
DO - 10.1177/1934578x0600100501
M3 - Article
AN - SCOPUS:34249669861
SN - 1934-578X
VL - 1
SP - 345
EP - 350
JO - Natural product communications
JF - Natural product communications
IS - 5
ER -