From structure to mechanism— understanding initiation of DNA replication

Alberto Riera, Marta Barbon, Yasunori Noguchi, L. Maximilian Reuter, Sarah Schneider, Christian Speck

研究成果: ジャーナルへの寄稿総説査読

64 被引用数 (Scopus)

抄録

DNA replication results in the doubling of the genome prior to cell division. This process requires the assembly of 50 or more protein factors into a replication fork. Here, we review recent structural and biochemical insights that start to explain how specific proteins recognize DNA replication origins, load the replicative helicase on DNA, unwind DNA, synthesize new DNA strands, and reassemble chromatin. We focus on the minichromosome maintenance (MCM2–7) proteins, which form the core of the eukaryotic replication fork, as this complex undergoes major structural rearrangements in order to engage with DNA, regulate its DNA-unwinding activity, and maintain genome stability.

本文言語英語
ページ(範囲)1073-1088
ページ数16
ジャーナルGenes and Development
31
11
DOI
出版ステータス出版済み - 2017
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 発生生物学

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