Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain

Shuya Yamashita, Tatsunori Yamashita, Koji Yamada, Hirofumi Tachibana

研究成果: ジャーナルへの寄稿学術誌査読

11 被引用数 (Scopus)

抄録

Immunoglobulin E (IgE) production is induced by interleukin (IL)-4 signaling mediated by type I IL-4 receptor (IL-4R) in B cells. We found that flavones inhibited IL-4-induced ε germline transcription which is essential for IgE class switching, and the phosphorylation of signal transducer and activator of transcription 6, janus kinase 3, and IL-4Rα, whereas IL-4 signaling mediated through type II IL-4R was unaffected by flavones. Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling.

本文言語英語
ページ(範囲)775-779
ページ数5
ジャーナルFEBS Letters
584
4
DOI
出版ステータス出版済み - 2月 2010

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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