First In Vivo Experience With Biventricular Circulatory Assistance Using a Single Continuous Flow Pump

Jamshid H. Karimov, David J. Horvath, Takuma Miyamoto, Yuichiro Kado, Shengqiang Gao, Barry D. Kuban, Anthony R. Polakowski, Shiva Sale, Kiyotaka Fukamachi

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)


Biventricular assist device (BVAD) implantation is the treatment of choice in patients with severe biventricular heart failure and cardiogenic shock. Our team has developed a miniaturized continuous flow, double-ended centrifugal pump intended for total artificial heart implant (CFTAH). The purpose of this initial in vivo study was to demonstrate that the scaled-down CFTAH (P-CFTAH) can be appropriate for BVAD support. The P-CFTAH was implanted in 4 acute lambs (average weight, 41.5 ± 2.8 kg) through a median sternotomy. The cannulation was performed through the left and right atria, and cannulae length adjustment was performed for atrial and ventricular cannulation. The BVAD system was tested at 3 pump speeds (3000, 4500, and 6000 rpm). The BVAD performed very well for both atrial and ventricular cannulation within the 3000–6000 rpm range. Stable hemodynamics were maintained after implantation of the P-CFTAH. The self-regulating performance of the system in vivo was demonstrated by the left (LAP) and right (RAP) pressure difference (LAP-RAP) falling predominantly within the range of −5 to 10 mm Hg with variation, in addition to in vitro assessment of left and right heart failure conditions. Left and right pump flows and total flow increased as the BVAD speed was increased. This initial in vivo testing of the BVAD system demonstrated satisfactory device performance and self-regulation for biventricular heart failure support over a wide range of conditions. The BVAD system keeps the atrial pressure difference within bounds and maintains acceptable cardiac output over a wide range of hemodynamic conditions.

ジャーナルSeminars in Thoracic and Cardiovascular Surgery
出版ステータス出版済み - 9月 1 2020

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 呼吸器内科
  • 循環器および心血管医学


「First In Vivo Experience With Biventricular Circulatory Assistance Using a Single Continuous Flow Pump」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。