Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis

Yuri Sonoda; Motoshi Sonoda; Kousuke Yonemoto; Masafumi Sanefuji; Ryoji Taira; Yoshitomo Motomura; Masataka Ishimura; Hiroyuki Torisu; Ryutaro Kira; Koichi Kusuhara; Yasunari Sakai; Shouichi Ohga

doi:10.1016/j.jneuroim.2021.577656

Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis

Yuri Sonoda, Motoshi Sonoda, Kousuke Yonemoto, Masafumi Sanefuji, Ryoji Taira, Yoshitomo Motomura, Masataka Ishimura, Hiroyuki Torisu, Ryutaro Kira, Koichi Kusuhara, Yasunari Sakai, Shouichi Ohga

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

4 被引用数 (Scopus)

抄録

Subacute sclerosing panencephalitis (SSPE) is a slow virus infection associated with mutant measles virus (MeV). The long-term outcome of antiviral treatments remains to be determined. We herein present a Japanese boy who was diagnosed with SSPE at 10 years of age. Intraventricular infusions of interferon-α effectively prevented the progress of symptoms during 14 years of follow-up period. Flow-cytometric analysis demonstrated higher proportion of T helper 17 cells (Th17, 18.2%) than healthy controls (4.8–14.5%) despite the normal subpopulation of peripheral lymphocytes. These data suggest that a group of patients with SSPE may show favorable responses to intraventricular infusions of interferon-α.

本文言語	英語
論文番号	577656
ジャーナル	Journal of Neuroimmunology
巻	358
DOI	https://doi.org/10.1016/j.jneuroim.2021.577656
出版ステータス	出版済み - 9月 15 2021

!!!All Science Journal Classification (ASJC) codes

免疫アレルギー学
免疫学
神経学
臨床神経学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1016/j.jneuroim.2021.577656

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title = "Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis",

abstract = "Subacute sclerosing panencephalitis (SSPE) is a slow virus infection associated with mutant measles virus (MeV). The long-term outcome of antiviral treatments remains to be determined. We herein present a Japanese boy who was diagnosed with SSPE at 10 years of age. Intraventricular infusions of interferon-α effectively prevented the progress of symptoms during 14 years of follow-up period. Flow-cytometric analysis demonstrated higher proportion of T helper 17 cells (Th17, 18.2%) than healthy controls (4.8–14.5%) despite the normal subpopulation of peripheral lymphocytes. These data suggest that a group of patients with SSPE may show favorable responses to intraventricular infusions of interferon-α.",

author = "Yuri Sonoda and Motoshi Sonoda and Kousuke Yonemoto and Masafumi Sanefuji and Ryoji Taira and Yoshitomo Motomura and Masataka Ishimura and Hiroyuki Torisu and Ryutaro Kira and Koichi Kusuhara and Yasunari Sakai and Shouichi Ohga",

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T1 - Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis

AU - Sonoda, Yuri

AU - Sonoda, Motoshi

AU - Yonemoto, Kousuke

AU - Sanefuji, Masafumi

AU - Taira, Ryoji

AU - Motomura, Yoshitomo

AU - Ishimura, Masataka

AU - Torisu, Hiroyuki

AU - Kira, Ryutaro

AU - Kusuhara, Koichi

AU - Sakai, Yasunari

AU - Ohga, Shouichi

PY - 2021/9/15

Y1 - 2021/9/15

N2 - Subacute sclerosing panencephalitis (SSPE) is a slow virus infection associated with mutant measles virus (MeV). The long-term outcome of antiviral treatments remains to be determined. We herein present a Japanese boy who was diagnosed with SSPE at 10 years of age. Intraventricular infusions of interferon-α effectively prevented the progress of symptoms during 14 years of follow-up period. Flow-cytometric analysis demonstrated higher proportion of T helper 17 cells (Th17, 18.2%) than healthy controls (4.8–14.5%) despite the normal subpopulation of peripheral lymphocytes. These data suggest that a group of patients with SSPE may show favorable responses to intraventricular infusions of interferon-α.

AB - Subacute sclerosing panencephalitis (SSPE) is a slow virus infection associated with mutant measles virus (MeV). The long-term outcome of antiviral treatments remains to be determined. We herein present a Japanese boy who was diagnosed with SSPE at 10 years of age. Intraventricular infusions of interferon-α effectively prevented the progress of symptoms during 14 years of follow-up period. Flow-cytometric analysis demonstrated higher proportion of T helper 17 cells (Th17, 18.2%) than healthy controls (4.8–14.5%) despite the normal subpopulation of peripheral lymphocytes. These data suggest that a group of patients with SSPE may show favorable responses to intraventricular infusions of interferon-α.

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AN - SCOPUS:85111832285

SN - 0165-5728

VL - 358

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 577656

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Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis

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!!!All Science Journal Classification (ASJC) codes

UN SDG

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