Fabrication of polymeric biomaterials: a strategy for tissue engineering and medical devices

Ferdous Khan, Masaru Tanaka, Sheikh Rafi Ahmad

研究成果: ジャーナルへの寄稿総説査読

176 被引用数 (Scopus)


Polymeric biomaterials have a significant impact in today's health care technology. Polymer hydrogels were the first experimentally designed biomaterials for human use. In this article the design, synthesis and properties of hydrogels, derived from synthetic and natural polymers, and their use as biomaterials in tissue engineering are reviewed. The stimuli-responsive hydrogels with controlled degradability and examples of suitable methods for designing such biomaterials, using multidisciplinary approaches from traditional polymer chemistry, materials engineering to molecular biology, have been discussed. Examples of the fabrication of polymer-based biomaterials, utilized for various cell type manipulations for tissue re-generation are also elaborated. Since a highly porous three-dimensional scaffold is crucially important in the cellular process, for tissue engineering, recent advances in the effective methods of scaffold fabrication are described. Additionally, the incorporation of factor molecules for the enhancement of tissue formation and their controlled release is also elucidated in this article. Finally, the future challenges in the efficient fabrication of effective polymeric biomaterials for tissue regeneration and medical device applications are discussed.

ジャーナルJournal of Materials Chemistry B
出版ステータス出版済み - 8月 21 2015

!!!All Science Journal Classification (ASJC) codes

  • 化学一般
  • 生体医工学
  • 材料科学一般


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