Expression of versican and ADAMTS during rat tooth eruption

Shinya Sone, Megumi Nakamura, Yuriko Maruya, Ichiro Takahashi, Itaru Mizoguchi, Hideaki Mayanagi, Yasuyuki Sasano

研究成果: ジャーナルへの寄稿学術誌査読

29 被引用数 (Scopus)

抄録

A disintegrin and metalloprotease with thrombospondin type 1 motifs (ADAMTS) is a family of extracellular proteases and implicated in cleaving proteoglycans, such as aggrecan, versican and brevican. No information is available about expression or localization of these ADAMTSs in teeth. Versican is a large chondroitin sulfate proteoglycan that is present in a variety of connective tissue including dental pulp, dentin, cementum and periodontal ligaments. The present study was designed to investigate expression of ADAMTSs and versican during rat tooth eruption. Rat maxillary first molars in weeks 1, 2, 3, 4 and 6 were examined. The mRNA expression of ADAMTS1, ADAMTS4, ADAMTS5 and versican was localized using in situ hybridization. ADAMTS1, ADAMTS4, ADAMTS5 and versican were expressed in dental pulp cells, odontoblasts, cementoblasts, cementocytes, periodontal ligament cells, osteoblasts and osteocytes. The temporal and spatial expression pattern in these cellular phenotypes was comparable among ADAMTSs and versican. The present study suggests that dental pulp cells, odontoblasts, cementoblasts, cementocytes, periodontal ligament cells, osteoblasts and osteocytes may be involved in both production and degradation of versican with secreting ADAMTS1, ADAMTS4 and ADAMTS5.

本文言語英語
ページ(範囲)281-288
ページ数8
ジャーナルJournal of Molecular Histology
36
4
DOI
出版ステータス出版済み - 5月 2005
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 組織学
  • 生理学
  • 細胞生物学

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