Expression of the type I collagen gene in rat periodontal ligament during tooth movement as revealed by in situ hybridization

Masahiro Nakagawa, Toshio Kukita, Akihiko Nakasima, Kojiro Kurisu

研究成果: ジャーナルへの寄稿学術誌査読

39 被引用数 (Scopus)

抄録

The in situ hybridization technique used digoxigenin-labelled oligodeoxynucleotide. In untreated molars, cells expressing a positive signal for type I collagen mRNA were distributed uniformly in the periodontal ligament space. After experimental tooth movement, the density of cells expressing a positive signal appeared to be much greater in the tension side than the pressure side. In both sides the distribution of the positively hybridizing cells was uniform along the principal fibres of the ligament. This characteristic distribution appeared at 12 h after the initiation of tooth movement, reached a maximum at 1-3 days, and persisted for about 14 days during the treatment. These results indicate that the remodelling of collagen fibres in periodontal ligament occurs in an orderly manner throughout the principal fibres, mainly on the tension side, and that the recovery of gene expression for type I collagen occurs within the first 14 days in response to experimental tooth movement.

本文言語英語
ページ(範囲)289-294
ページ数6
ジャーナルArchives of Oral Biology
39
4
DOI
出版ステータス出版済み - 4月 1994

!!!All Science Journal Classification (ASJC) codes

  • 耳鼻咽喉科学
  • 歯学一般
  • 細胞生物学

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