Enantioselective Synthesis of Silacyclopentanes

Kazunobu Igawa; Daisuke Yoshihiro; Yusuke Abe; Katsuhiko Tomooka

doi:10.1002/anie.201511728

Enantioselective Synthesis of Silacyclopentanes

Kazunobu Igawa, Daisuke Yoshihiro, Yusuke Abe, Katsuhiko Tomooka

分子集積化学部門

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

36 被引用数 (Scopus)

抄録

A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β-eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β-elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.

本文言語	英語
ページ（範囲）	5814-5818
ページ数	5
ジャーナル	Angewandte Chemie - International Edition
巻	55
号	19
DOI	https://doi.org/10.1002/anie.201511728
出版ステータス	出版済み - 5月 4 2016

!!!All Science Journal Classification (ASJC) codes

触媒
化学一般

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10.1002/anie.201511728

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abstract = "A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β-eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β-elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.",

author = "Kazunobu Igawa and Daisuke Yoshihiro and Yusuke Abe and Katsuhiko Tomooka",

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AU - Igawa, Kazunobu

AU - Yoshihiro, Daisuke

AU - Abe, Yusuke

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PY - 2016/5/4

Y1 - 2016/5/4

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AB - A variety of functionalized silacyclopentanes were synthesized by highly enantioselective β-eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β-elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.

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Enantioselective Synthesis of Silacyclopentanes

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!!!All Science Journal Classification (ASJC) codes

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