TY - JOUR
T1 - Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis
AU - Furue, Masutaka
AU - Yamamura, K.
AU - Kido-Nakahara, M.
AU - Nakahara, T.
AU - Fukui, Y.
N1 - Funding Information:
This research is supported by the Leading Advanced Projects for Medical Innovation (LEAP; to Y.F.) and the Research on Development of New Drugs (to Y.F.) from Japan Agency for Medical Research and Development (AMED); and Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to Y.F.).
Publisher Copyright:
© 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
PY - 2018/1
Y1 - 2018/1
N2 - Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from TH2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.
AB - Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper 2 (TH2)-deviated immune reactions. Interleukin-31 (IL-31), preferentially produced from TH2 cells, is a potent pruritogenic cytokine, and its systemic and local administration induces scratching behavior in rodents, dogs and monkeys. Recent clinical trials have revealed that administration of an anti-IL-31 receptor antibody significantly alleviates pruritus in patients with AD. In this review, we summarize recent topics related to IL-31 and its receptor with special references to atopic itch.
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U2 - 10.1111/all.13239
DO - 10.1111/all.13239
M3 - Review article
C2 - 28670717
AN - SCOPUS:85025435358
SN - 0105-4538
VL - 73
SP - 29
EP - 36
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 1
ER -