TY - JOUR
T1 - Elevated serum glycated albumin and glycated albumin : hemoglobin A1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese
T2 - The Hisayama Study
AU - Ohara, Tomoyuki
AU - Furuta, Yoshihiko
AU - Hirabayashi, Naoki
AU - Hata, Jun
AU - Hirakawa, Yoichiro
AU - Honda, Takanori
AU - Yoshida, Daigo
AU - Shibata, Mao
AU - Kitazono, Takanari
AU - Ninomiya, Toshiharu
N1 - Funding Information:
The authors thank the residents of Hisayama town for their participation in the present examination. We are also grateful to the staff members of the Division of Health and Welfare of Hisayama for their cooperation with the present work. We carried out statistical analyses by using the computer resources of General Projects by Research Institute for Information Technology, Kyushu University. This study was supported in part by Health and Labor Sciences Research Grants of the Ministry of Health, Labor and Welfare of Japan (H30-Shokuhin-[Sitei]-005 and H29-Junkankitou-Ippan-003); by Grants-in-Aid for Scientific Research (A) (JP16H02692), (B) (JP18H02737, JP17H04126 and JP16H05850), (C) (JP19K07890, JP18K09412, JP18K07565, JP17K01853, JP17K09113 and JP17K09114), and (Early-Career Scientists; JP18K17382 and JP18K17925) from the Ministry of Education, Culture, Sports, Science and Technology of Japan; and by grants from the Japan Agency for Medical Research and Development (JP19km0405202, JP19fk0108075, JP19ek0210080 JP19ek0210083, JP19ek0210082 and JP19dk0207025). Each study sponsor did not have any role in the study design, interpretation of the data, data collection or drafting the manuscript.
Funding Information:
The authors thank the residents of Hisayama town for their participation in the present examination. We are also grateful to the staff members of the Division of Health and Welfare of Hisayama for their cooperation with the present work. We carried out statistical analyses by using the computer resources of General Projects by Research Institute for Information Technology, Kyushu University. This study was supported in part by Health and Labor Sciences Research Grants of the Ministry of Health, Labor and Welfare of Japan (H30‐Shokuhin‐[Sitei]‐005 and H29‐Junkankitou‐Ippan‐003); by Grants‐in‐Aid for Scientific Research (A) (JP16H02692), (B) (JP18H02737, JP17H04126 and JP16H05850), (C) (JP19K07890, JP18K09412, JP18K07565, JP17K01853, JP17K09113 and JP17K09114), and (Early‐Career Scientists; JP18K17382 and JP18K17925) from the Ministry of Education, Culture, Sports, Science and Technology of Japan; and by grants from the Japan Agency for Medical Research and Development (JP19km0405202, JP19fk0108075, JP19ek0210080 JP19ek0210083, JP19ek0210082 and JP19dk0207025). Each study sponsor did not have any role in the study design, interpretation of the data, data collection or drafting the manuscript.
Publisher Copyright:
© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Aims/Introduction: To investigate the association of alternative glycemic measures – namely, serum glycated albumin (GA), hemoglobin A1c (HbA1c) and the GA : HbA1c ratio – with global brain and hippocampal atrophy in a general elderly Japanese population. Materials and Methods: A total of 1,278 Japanese individuals aged ≥65 years in a community participated in brain magnetic resonance imaging scanning and screening examination of health status in 2012. We measured total brain volume (TBV), hippocampal volume (HV) and intracranial volume (ICV) using the data from the magnetic resonance imaging examination. The association of each glycemic measure with the ratios of TBV : ICV (an indicator of global brain atrophy) and HV : ICV (an indicator of hippocampal atrophy) was examined by analysis of covariance. Results: The mean values of the TBV : ICV and HV : ICV ratios decreased significantly with elevating serum GA levels and GA : HbA1c ratio levels (all P for trend < 0.05), but not with higher HbA1c levels, after adjusting for age, sex, low education, systolic blood pressure, antihypertensive medication, diabetes mellitus, serum total cholesterol, electrocardiogram abnormalities, body mass index, smoking habits, alcohol drinking habits and regular exercise. These significant associations were still observed in the sensitivity analysis after excluding individuals with mild cognitive impairment and dementia. In addition, increased serum GA levels and the GA : HbA1c ratio levels, but not HbA1c, were closely associated with lower mean values of the TBV : ICV and HV : ICV ratios, irrespective of the presence or absence of diabetes mellitus. Conclusions: The present study suggests that higher serum GA and higher GA : HbA1c ratio are significantly associated with global brain and hippocampal atrophy.
AB - Aims/Introduction: To investigate the association of alternative glycemic measures – namely, serum glycated albumin (GA), hemoglobin A1c (HbA1c) and the GA : HbA1c ratio – with global brain and hippocampal atrophy in a general elderly Japanese population. Materials and Methods: A total of 1,278 Japanese individuals aged ≥65 years in a community participated in brain magnetic resonance imaging scanning and screening examination of health status in 2012. We measured total brain volume (TBV), hippocampal volume (HV) and intracranial volume (ICV) using the data from the magnetic resonance imaging examination. The association of each glycemic measure with the ratios of TBV : ICV (an indicator of global brain atrophy) and HV : ICV (an indicator of hippocampal atrophy) was examined by analysis of covariance. Results: The mean values of the TBV : ICV and HV : ICV ratios decreased significantly with elevating serum GA levels and GA : HbA1c ratio levels (all P for trend < 0.05), but not with higher HbA1c levels, after adjusting for age, sex, low education, systolic blood pressure, antihypertensive medication, diabetes mellitus, serum total cholesterol, electrocardiogram abnormalities, body mass index, smoking habits, alcohol drinking habits and regular exercise. These significant associations were still observed in the sensitivity analysis after excluding individuals with mild cognitive impairment and dementia. In addition, increased serum GA levels and the GA : HbA1c ratio levels, but not HbA1c, were closely associated with lower mean values of the TBV : ICV and HV : ICV ratios, irrespective of the presence or absence of diabetes mellitus. Conclusions: The present study suggests that higher serum GA and higher GA : HbA1c ratio are significantly associated with global brain and hippocampal atrophy.
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U2 - 10.1111/jdi.13220
DO - 10.1111/jdi.13220
M3 - Article
C2 - 31999889
AN - SCOPUS:85081012237
SN - 2040-1116
VL - 11
SP - 971
EP - 979
JO - Journal of Diabetes Investigation
JF - Journal of Diabetes Investigation
IS - 4
ER -
