Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis

Fumie Hayashi, Noriko Isobe, Davide Cossu, Kazumasa Yokoyama, Ayako Sakoda, Takuya Matsushita, Nobutaka Hattori, Jun ichi Kira

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

To investigate whether antibody production against mycobacterium avium subsp. paratuberculosis (MAP) is related to clinical characteristics of multiple sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody against three MAP peptides and two human peptides homologous to MAP were measured in sera from 103 MS patients and 50 healthy controls (HCs). MS patients had higher IgG levels against MAP2694295–303 (MAP2694-IgG) than HCs, while the other antibodies were comparable. Multivariate analysis demonstrated that higher MAP2694-IgG titers were associated with higher EDSS scores, but not with HLA alleles or dairy product consumption. Immune response against MAP may worsen MS disability.

本文言語英語
論文番号577701
ジャーナルJournal of Neuroimmunology
360
DOI
出版ステータス出版済み - 11月 15 2021

!!!All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

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