Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension

Keimei Yoshida, Keita Saku, Kazuhiro Kamada, Kohtaro Abe, Mariko Tanaka-Ishikawa, Takeshi Tohyama, Takuya Nishikawa, Takuya Kishi, Kenji Sunagawa, Hiroyuki Tsutsui

研究成果: ジャーナルへの寄稿学術誌査読

30 被引用数 (Scopus)

抄録

This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a SU5416 injection) and treatment (VNS from 5 to 10 weeks) protocols. Thus, VNS may serve as a novel therapeutic strategy for pulmonary arterial hypertension.

本文言語英語
ページ(範囲)657-671
ページ数15
ジャーナルJACC: Basic to Translational Science
3
5
DOI
出版ステータス出版済み - 10月 2018

!!!All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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