Effects of three different highly purified n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/KsJ-dbl db mice

Naohiro Gotoh, Koji Nagao, Satoru Onoda, Bungo Shirouchi, Renta Furuya, Toshiharu Nagai, Hoyo Mizobe, Kenji Ichioka, Hiroyuki Watanabe, Teruyoshiy Anagita, Shun Wada

研究成果: ジャーナルへの寄稿学術誌査読

65 被引用数 (Scopus)

抄録

Triglycerides (TG) consisting of highly purified (>97%) n-3 series highly unsaturated fatty acids, eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), were administered to C57BL/KsJ-dbl db mice for 4 weeks by pair-feeding to compare their effects on lipid metabolism and to evaluate the effects of DPA on lipid metabolism. The hepatic TG level and total amount was decreased by treatment with DHA and DPA compared to the control. The efficacy of DPA was greater than that of EPA, but less than that of DHA. In contrast, EPA had the greatest serum TG reducing effect. The hepatic cytosol fraction of the DHA-treated group contained the lowest fatty acid synthase (FAS) and malic enzyme (ME) activity levels. Furthermore, the DHA-treated group contained the highest serum adiponectin concentrations. These findings indicate that the strong hepatic TGlowering effect of DHA is due to the suppression of TG synthesis. The same tendencies were observed in DPA-treated mice, and the effect was stronger than that observed in EPA-treated mice, but equivalent to that observed in DHA-treated mice. Based on these results, DPA possesses lipid metabolism-improving effects. The beneficial effects of DPA for lipid metabolism were not superior to those of EPA and DHA, and the effect was always intermediate between those of EPA and DHA.

本文言語英語
ページ(範囲)11047-11054
ページ数8
ジャーナルJournal of Agricultural and Food Chemistry
57
22
DOI
出版ステータス出版済み - 11月 25 2009
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 化学一般
  • 農業および生物科学一般

フィンガープリント

「Effects of three different highly purified n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/KsJ-dbl db mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル