Effects of telephone-delivered lifestyle support on the development of diabetes in participants at high risk of type 2 diabetes: J-DOIT1, a pragmatic cluster randomised trial

Naoki Sakane, Kazuhiko Kotani, Kaoru Takahashi, Yoshiko Sano, Kokoro Tsuzaki, Kentaro Okazaki, Juichi Sato, Sadao Suzuki, Satoshi Morita, Yoshitake Oshima, Kazuo Izumi, Masayuki Kato, Naoki Ishizuka, Mitsuhiko Noda, Hideshi Kuzuya

研究成果: ジャーナルへの寄稿学術誌査読

26 被引用数 (Scopus)

抄録

Objectives: To examine the effects of telephonedelivered lifestyle coaching on preventing the development of type 2 diabetes mellitus (T2DM) in participants with impaired fasting glucose (IFG). Design: Cluster randomised trial. Setting: 40 groups from 17 healthcare divisions in Japan: companies (31), communities (6) and mixed settings (3). Participants: Participants aged 20-65 years with fasting plasma glucose (FPG) of 5.6-6.9 mmol/L were invited from the 17 healthcare divisions. Randomisation: The groups were then randomly assigned to an intervention or a control arm by independent statisticians according to a computergenerated list. Intervention: The intervention arm received a 1-year telephone-delivered intervention provided by three private lifestyle support centres (at different frequencies: low-frequency (3 times), middle-frequency (6 times) and high-frequency (10 times) support calls). The intervention and control arms both received selfhelp devices such as a weight scale and pedometer. Outcomes: Participants were followed up using data from annual health check-ups and a questionnaire regarding lifestyle. The primary outcome was the development of T2DM defined as FPG ≥7.0 mmol/L, the diagnosis of diabetes, or use of an antidiabetic drug, confirmed by referring to medical cards. Results: Of 14 473 screened individuals, participants were enrolled in either the intervention (n=1240) arm or control (n=1367) arm. Overall, the HR for the development of T2DM in the intervention arm during 5.5 years was 1.00 (95% CI 0.74 to 1.34). In the subanalysis, the HR was 0.59 (95% CI 0.42 to 0.83) in the subgroup that received phone calls the most frequently, compared with the control arm. A limitation of the study includes a lack of blinding. Conclusions: High-frequency telephone-delivered lifestyle support could effectively prevent T2DM in participants with IFG in a primary healthcare setting, although low-frequency and middle-frequency phone calls did not.

本文言語英語
論文番号e007316
ジャーナルBMJ open
5
8
DOI
出版ステータス出版済み - 2015
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 医学一般

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