Effects of Substituents on the Properties of Metal-Free MRI Contrast Agents

Ryoma Shiraishi, Tomoyo Kaneko, Kazuteru Usui, Tatsuya Naganuma, Naoko Iizuka, Kosuke Morishita, Shigeki Kobayashi, Yasufumi Fuchi, Yuta Matsuoka, Go Hirai, Ken Ichi Yamada, Satoru Karasawa

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)


Materials possessing electron spin can shorten the T1 relaxation times in magnetic resonance imaging (MRI). For example, gadolinium (Gd) complexes with seven f-orbital electrons are widely used as contrast agents in clinical applications. However, Gd has severe potential side effects, and thus metal-free alternatives are needed. Toward this end, we synthesized seven NO radicals consisting of a dioxa-azaspiro[4.5]decane framework having various substituents, DAD-X (X = methyl, ethyl, n-propyl, c-propyl, vinyl, phenyl, and 2-pyridyl), that functioned as metal-free MRI contrast agents. The relationship between (i) water-proton relaxivity and log※P and (ii) reactivity for ascorbic acid and the spin density of the NO oxygen atom were established, which provided a basis for the rational design of practical metal-free contrast agents.

ジャーナルACS Omega
出版ステータス出版済み - 12月 10 2019

!!!All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 化学工学(全般)


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