Dipyridamole potentiates adriamycin cytotoxicity by a mechanism other than inhibiting nucleoside uptake

H. Kusumoto, Y. Maehara, H. Anai, R. Kumashiro, K. Sugimachi

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

Nitrobenzylthioinosine (NBTI) and dipyridamole (DP) are competitive inhibitors of cellular nucleoside uptake. Although combined treatment of HeLa cells with adriamycin (ADM) and DP enhanced ADM cytotoxicity in cell growth and clonogenic assays, the combination of ADM and noncytostatic levels (less than 1 μM) of NBTI did not change the cytotoxic potential of ADM in vitro. DP enhanced the inhibition of clonogenicity by ADM, even in nucleoside-enriched mediums. These results suggest that the synergy between ADM and DP was hardly due to the inhibition of nucleoside uptake by DP, but was due to the enhancement of intracellular ADM accumulation by DP.

本文言語英語
ページ(範囲)1539-1542
ページ数4
ジャーナルAnticancer research
11
4
出版ステータス出版済み - 1991

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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