Differential requirement for D0CK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells

Kazuhito Gotoh, Yoshihiko Tanaka, Akihiko Nishikimi, Ayumi Inayoshi, Munechika Enjoji, Ryoichi Takayanagi, Takehiko Sasazuki, Yoshinori Fukui

研究成果: ジャーナルへの寄稿学術誌査読

62 被引用数 (Scopus)

抄録

The migratory properties of dendritic cells (DCs) are important for their functions. Although several chemokines and their receptors have been implicated in DC migration, the downstream signaling molecules are largely unknown. Here we show that DOCK2, a hematopoietic cell-specific CDM family protein, is indispensable for migration of plasmacytoid DCs (pDCs), but not myeloid DCs (mDCs). Although DOCK2-deficiency did not affect development of pDCs, DOCK2-deficient (DOCK2-1) mice exhibited a severe reduction of pDCs in the spleen and lymph nodes. Adoptive transfer experiments revealed that DOCK2-/- pDCs failed to migrate into the periarteriolar lymphoid sheaths of the spleen. In DOCK2-/- pDCs, chemokine-induced Rac activation was severely impaired, resulting in the reduction of motility and the loss of polarity during chemotaxis. In contrast, DOCK2-/- mDCs did not show any defects in Rac activation and migration. These results indicate that pDCs and mDCs use distinct molecules to activate Rac during chemotaxis.

本文言語英語
ページ(範囲)2973-2976
ページ数4
ジャーナルBlood
111
6
DOI
出版ステータス出版済み - 3月 15 2008

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 免疫学
  • 血液学
  • 細胞生物学

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