Development and performance evaluation of a deep learning lung nodule detection system

Shichiro Katase, Akimichi Ichinose, Mahiro Hayashi, Masanaka Watanabe, Kinka Chin, Yuhei Takeshita, Hisae Shiga, Hidekatsu Tateishi, Shiro Onozawa, Yuya Shirakawa, Koji Yamashita, Jun Shudo, Keigo Nakamura, Akihito Nakanishi, Kazunori Kuroki, Kenichi Yokoyama

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)


Background: Lung cancer is the leading cause of cancer-related deaths throughout the world. Chest computed tomography (CT) is now widely used in the screening and diagnosis of lung cancer due to its effectiveness. Radiologists must identify each small nodule shadow from 3D volume images, which is very burdensome and often results in missed nodules. To address these challenges, we developed a computer-aided detection (CAD) system that automatically detects lung nodules in CT images. Methods: A total of 1997 chest CT scans were collected for algorithm development. The algorithm was designed using deep learning technology. In addition to evaluating detection performance on various public datasets, its robustness to changes in radiation dose was assessed by a phantom study. To investigate the clinical usefulness of the CAD system, a reader study was conducted with 10 doctors, including inexperienced and expert readers. This study investigated whether the use of the CAD as a second reader could prevent nodular lesions in lungs that require follow-up examinations from being overlooked. Analysis was performed using the Jackknife Free-Response Receiver-Operating Characteristic (JAFROC). Results: The CAD system achieved sensitivity of 0.98/0.96 at 3.1/7.25 false positives per case on two public datasets. Sensitivity did not change within the range of practical doses for a study using a phantom. A second reader study showed that the use of this system significantly improved the detection ability of nodules that could be picked up clinically (p = 0.026). Conclusions: We developed a deep learning-based CAD system that is robust to imaging conditions. Using this system as a second reader increased detection performance.

ジャーナルBMC Medical Imaging
出版ステータス出版済み - 12月 2022

!!!All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング


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