Designing stem cell niches for differentiation and self-renewal

Hannah Donnelly, Manuel Salmeron-Sanchez, Matthew J. Dalby

研究成果: ジャーナルへの寄稿総説査読

96 被引用数 (Scopus)


Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in contact with their specialized microenvironment, termed the stem cell niche. Niches provide structural and functional cues that are both biochemical and biophysical, stem cells integrate this complex array of signals with intrinsic regulatory networks to meet physiological demands. Although, some of these regulatory mechanisms remain poorly understood or difficult to harness with traditional culture systems. Biomaterial strategies are being developed that aim to recapitulate stem cell niches, by engineering microenvironments with physiological-like niche properties that aim to elucidate stem cell-regulatory mechanisms, and to harness their regenerative capacity in vitro. In the future, engineered niches will prove important tools for both regenerative medicine and therapeutic discoveries.

ジャーナルJournal of the Royal Society Interface
出版ステータス出版済み - 2018

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 生物理学
  • バイオエンジニアリング
  • 生体材料
  • 生化学
  • 生体医工学


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