Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure

Shigeki Sasaki; Tomohiro Hashimoto; Norihiro Obana; Hideyo Yasuda; Yoshimasa Uehara; Minoru Maeda

doi:10.1016/S0960-894X(98)00163-2

Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure

Shigeki Sasaki
, Tomohiro Hashimoto
, Norihiro Obana
, Hideyo Yasuda
, Yoshimasa Uehara
, Minoru Maeda

医薬化学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

18 被引用数 (Scopus)

抄録

New inhibitors have been designed for cdc2 kinase based on a multiple pseudosubstrate structure. The new inhibitors have three different structural components: 3,4-bis(indol-3-yl)maleimide, Ac-Cys-(Ser)-Pro-Lys-Lys-NHMe, and ethyloxy group between the two components. Inhibitory activities toward cdc2 and other protein kinases were investigated, and the compound (21) with Ac- Cys-Pro-Lys-Lys-NHMe connected with the triethylene glycol spacer exhibited the most potent inhibition with relatively high selectivity.

本文言語	英語
ページ（範囲）	1019-1022
ページ数	4
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	8
号	9
DOI	https://doi.org/10.1016/S0960-894X(98)00163-2
出版ステータス	出版済み - 5月 1998

!!!All Science Journal Classification (ASJC) codes

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

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10.1016/S0960-894X(98)00163-2

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title = "Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure",

abstract = "New inhibitors have been designed for cdc2 kinase based on a multiple pseudosubstrate structure. The new inhibitors have three different structural components: 3,4-bis(indol-3-yl)maleimide, Ac-Cys-(Ser)-Pro-Lys-Lys-NHMe, and ethyloxy group between the two components. Inhibitory activities toward cdc2 and other protein kinases were investigated, and the compound (21) with Ac- Cys-Pro-Lys-Lys-NHMe connected with the triethylene glycol spacer exhibited the most potent inhibition with relatively high selectivity.",

author = "Shigeki Sasaki and Tomohiro Hashimoto and Norihiro Obana and Hideyo Yasuda and Yoshimasa Uehara and Minoru Maeda",

year = "1998",

month = may,

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure

AU - Sasaki, Shigeki

AU - Hashimoto, Tomohiro

AU - Obana, Norihiro

AU - Yasuda, Hideyo

AU - Uehara, Yoshimasa

AU - Maeda, Minoru

PY - 1998/5

Y1 - 1998/5

N2 - New inhibitors have been designed for cdc2 kinase based on a multiple pseudosubstrate structure. The new inhibitors have three different structural components: 3,4-bis(indol-3-yl)maleimide, Ac-Cys-(Ser)-Pro-Lys-Lys-NHMe, and ethyloxy group between the two components. Inhibitory activities toward cdc2 and other protein kinases were investigated, and the compound (21) with Ac- Cys-Pro-Lys-Lys-NHMe connected with the triethylene glycol spacer exhibited the most potent inhibition with relatively high selectivity.

AB - New inhibitors have been designed for cdc2 kinase based on a multiple pseudosubstrate structure. The new inhibitors have three different structural components: 3,4-bis(indol-3-yl)maleimide, Ac-Cys-(Ser)-Pro-Lys-Lys-NHMe, and ethyloxy group between the two components. Inhibitory activities toward cdc2 and other protein kinases were investigated, and the compound (21) with Ac- Cys-Pro-Lys-Lys-NHMe connected with the triethylene glycol spacer exhibited the most potent inhibition with relatively high selectivity.

UR - https://www.scopus.com/pages/publications/0032080613

UR - https://www.scopus.com/pages/publications/0032080613#tab=citedBy

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DO - 10.1016/S0960-894X(98)00163-2

M3 - Article

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AN - SCOPUS:0032080613

SN - 0960-894X

VL - 8

SP - 1019

EP - 1022

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure

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!!!All Science Journal Classification (ASJC) codes

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