Demyelinating Neuropathy with Markedly Elevated Serum IgG4 Levels and Anti-Contactin 1 IgG4 Antibody

Taiki Fukushima; Shohei Ikeda; Minoru Tomita; Yu Mori; Yuki Fukami; Haruki Koike; Masahisa Katsuno; Hidenori Ogata; Noriko Isobe; Naoki Hattori

doi:10.2169/internalmedicine.9286-21

Demyelinating Neuropathy with Markedly Elevated Serum IgG4 Levels and Anti-Contactin 1 IgG4 Antibody

Taiki Fukushima, Shohei Ikeda, Minoru Tomita, Yu Mori, Yuki Fukami, Haruki Koike, Masahisa Katsuno, Hidenori Ogata, Noriko Isobe, Naoki Hattori

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

2 被引用数 (Scopus)

抄録

We herein report a 77-year-old man with a 4-month history of progressive gait and sensory disturbances of the extremities. A nerve conduction study indicated demyelinating polyneuropathy. Serum IgG4 levels and anti-contactin 1 IgG4 antibodies were markedly increased. The sural nerve biopsy specimen showed IgG4- positive plasma cell infiltration in the epineurium. Treatment with steroids resulted in an amelioration of functional status, improvement of nerve conduction parameters, decreased serum IgG4 levels, and negative conversion of anti-contactin 1 antibody. Further studies are needed to clarify the significance of IgG4-positive plasma cell infiltration in anti-contactin 1 antibody-positive neuropathies.

本文言語	英語
ページ（範囲）	1341-1344
ページ数	4
ジャーナル	Internal Medicine
巻	62
号	9
DOI	https://doi.org/10.2169/internalmedicine.9286-21
出版ステータス	出版済み - 2023

!!!All Science Journal Classification (ASJC) codes

内科学

文献へのアクセス

10.2169/internalmedicine.9286-21

他のファイルとリンク

引用スタイル

@article{812858103200487cb491737233a39a7c,

title = "Demyelinating Neuropathy with Markedly Elevated Serum IgG4 Levels and Anti-Contactin 1 IgG4 Antibody",

abstract = "We herein report a 77-year-old man with a 4-month history of progressive gait and sensory disturbances of the extremities. A nerve conduction study indicated demyelinating polyneuropathy. Serum IgG4 levels and anti-contactin 1 IgG4 antibodies were markedly increased. The sural nerve biopsy specimen showed IgG4- positive plasma cell infiltration in the epineurium. Treatment with steroids resulted in an amelioration of functional status, improvement of nerve conduction parameters, decreased serum IgG4 levels, and negative conversion of anti-contactin 1 antibody. Further studies are needed to clarify the significance of IgG4-positive plasma cell infiltration in anti-contactin 1 antibody-positive neuropathies.",

keywords = "Chronic inflammatory demyelinating polyneuropathy, contactin 1, intravenous immunoglobulin therapy, steroid therapy",

author = "Taiki Fukushima and Shohei Ikeda and Minoru Tomita and Yu Mori and Yuki Fukami and Haruki Koike and Masahisa Katsuno and Hidenori Ogata and Noriko Isobe and Naoki Hattori",

year = "2023",

doi = "10.2169/internalmedicine.9286-21",

language = "English",

volume = "62",

pages = "1341--1344",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "9",

}

TY - JOUR

T1 - Demyelinating Neuropathy with Markedly Elevated Serum IgG4 Levels and Anti-Contactin 1 IgG4 Antibody

AU - Fukushima, Taiki

AU - Ikeda, Shohei

AU - Tomita, Minoru

AU - Mori, Yu

AU - Fukami, Yuki

AU - Koike, Haruki

AU - Katsuno, Masahisa

AU - Ogata, Hidenori

AU - Isobe, Noriko

AU - Hattori, Naoki

PY - 2023

Y1 - 2023

N2 - We herein report a 77-year-old man with a 4-month history of progressive gait and sensory disturbances of the extremities. A nerve conduction study indicated demyelinating polyneuropathy. Serum IgG4 levels and anti-contactin 1 IgG4 antibodies were markedly increased. The sural nerve biopsy specimen showed IgG4- positive plasma cell infiltration in the epineurium. Treatment with steroids resulted in an amelioration of functional status, improvement of nerve conduction parameters, decreased serum IgG4 levels, and negative conversion of anti-contactin 1 antibody. Further studies are needed to clarify the significance of IgG4-positive plasma cell infiltration in anti-contactin 1 antibody-positive neuropathies.

AB - We herein report a 77-year-old man with a 4-month history of progressive gait and sensory disturbances of the extremities. A nerve conduction study indicated demyelinating polyneuropathy. Serum IgG4 levels and anti-contactin 1 IgG4 antibodies were markedly increased. The sural nerve biopsy specimen showed IgG4- positive plasma cell infiltration in the epineurium. Treatment with steroids resulted in an amelioration of functional status, improvement of nerve conduction parameters, decreased serum IgG4 levels, and negative conversion of anti-contactin 1 antibody. Further studies are needed to clarify the significance of IgG4-positive plasma cell infiltration in anti-contactin 1 antibody-positive neuropathies.

KW - Chronic inflammatory demyelinating polyneuropathy

KW - contactin 1

KW - intravenous immunoglobulin therapy

KW - steroid therapy

UR - http://www.scopus.com/inward/record.url?scp=85159254134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85159254134&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.9286-21

DO - 10.2169/internalmedicine.9286-21

M3 - Article

C2 - 35908968

AN - SCOPUS:85159254134

SN - 0918-2918

VL - 62

SP - 1341

EP - 1344

JO - Internal Medicine

JF - Internal Medicine

IS - 9

ER -

Demyelinating Neuropathy with Markedly Elevated Serum IgG4 Levels and Anti-Contactin 1 IgG4 Antibody

抄録

!!!All Science Journal Classification (ASJC) codes

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル