Delta-9-Tetrahydrocannabinol and Catalepsy-Like Immobilization

N. Egashira

研究成果: 書籍/レポート タイプへの寄稿

1 被引用数 (Scopus)


The present article introduces studies related to catalepsy-like immobilization induced by delta-9-tetrahydrocannabinol (THC), the major psychoactive component of marijuana. THC induces catalepsy-like immobilization, and this behavior is antagonized by the cannabinoid (CB)1 receptor antagonist rimonabant. Also, the microinjection of THC into the nucleus accumbens induces catalepsy-like immobilization, and THC-induced catalepsy-like immobilization is prevented by lesions in the nucleus accumbens. 5-Hydroxytryptamine (5-HT) receptor agonists inhibit THC-induced catalepsy-like immobilization. In contrast, 5-HT receptor antagonists enhance THC-induced catalepsy-like immobilization. THC-induced catalepsy-like immobilization is also prevented by MK-801 and amantadine. THC decreased extracellular 5-HT levels in rat nucleus accumbens, and this effect was antagonized by rimonabant. Moreover, MK-801 abolished this THC-induced decrease in 5-HT releases. Taken together, these results demonstrate that CB1-mediated, THC-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens, due to the action of glutamate-containing neurons.

ホスト出版物のタイトルHandbook of Cannabis and Related Pathologies
ホスト出版物のサブタイトルBiology, Pharmacology, Diagnosis, and Treatment
出版社Elsevier Inc.
出版ステータス出版済み - 1月 24 2017

!!!All Science Journal Classification (ASJC) codes

  • 医学一般
  • 神経科学一般


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