TY - JOUR
T1 - Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation
AU - Morishita, Hideaki
AU - Eguchi, Satoshi
AU - Kimura, Hirotaka
AU - Sasaki, Junko
AU - Sakamaki, Yuriko
AU - Robinson, Michael L.
AU - Sasaki, Takehiko
AU - Mizushima, Noboru
PY - 2013/4/19
Y1 - 2013/4/19
N2 - Background: The role of autophagy-dependent quality control in the lens remains unclear. Results: Deletion of Atg5 and Pik3c3/Vps34 in the lens does not affect programmed organelle degradation but causes cataract and a developmental defect, respectively. Conclusion: These genes are important for quality control and development of the lens. Significance: This study provides new insights into biology and age-related pathology of the lens.
AB - Background: The role of autophagy-dependent quality control in the lens remains unclear. Results: Deletion of Atg5 and Pik3c3/Vps34 in the lens does not affect programmed organelle degradation but causes cataract and a developmental defect, respectively. Conclusion: These genes are important for quality control and development of the lens. Significance: This study provides new insights into biology and age-related pathology of the lens.
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U2 - 10.1074/jbc.M112.437103
DO - 10.1074/jbc.M112.437103
M3 - Article
C2 - 23479732
AN - SCOPUS:84876570034
SN - 0021-9258
VL - 288
SP - 11436
EP - 11447
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 16
ER -