Construction of 3D tissue-like structure using functional magnetite nanoparticles

Akira Ito, Hiroyuki Honda, Masamichi Kamihira

研究成果: ジャーナルへの寄稿総説査読

4 被引用数 (Scopus)


Magnetic nanoparticles for medical applications have been developed by many researchers. Since these nanoparticles have unique magnetic features not present in other materials, they can be applied to special medical techniques. Magnetite cationic liposomes (MCLs), one group of the cationic magnetic particles, can be used as carriers to introduce magnetite nanoparticles into target cells since their positively charged surface interacts with the negatively charged cell surface. Magnetite nanoparticles conjugated with antibodies (antibody-conjugated magnetoliposomes, AMLs) are applicable to introduce magnetite nanoparticles specifically into target cells, even when target cells coexist with other kinds of cells. Since the cells labeled with magnetite nanoparticles could be manipulated using magnets, we applied this technique to tissue engineering and termed it 'magnetic force-based tissue engineering (Mag-TE)'. Both magnetic force and functionalized magnetite nanoparticles were used in a process of tissue engineering: construction of multilayered cell sheet-like structures and tubular structures. Thus, the applications of these functionalized magnetite nanoparticles with their unique features will further improve tissue engineering techniques.

ジャーナルYakugaku Zasshi
出版ステータス出版済み - 1月 2008

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学


「Construction of 3D tissue-like structure using functional magnetite nanoparticles」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。