Connexins in health and disease

研究成果: ジャーナルへの寄稿総説査読

18 被引用数 (Scopus)

抄録

Gap junctions or hemichannels are expressed on all cells in our body, and have a highly significant role in homeostasis and in disease states. There are 21 connexins found in humans and they have distinct characteristics that compensate for each other. The anatomical expression pattern also differs between each connexin; some of them are expressed together and some are not. Genetically mutated connexin genes induce inheritable diseases, but acquired disorders can also be caused by primary or secondary connexin dysfunctions. In the central nervous system, glial cells are the main connexin-expressing cells. They utilize connexin gap junctions to assemble glial networks. The present review not only describes the basic structures and functions of connexins, it also examines the relationships between connexins and their role in disease pathology.

本文言語英語
ページ(範囲)30-36
ページ数7
ジャーナルClinical and Experimental Neuroimmunology
9
DOI
出版ステータス出版済み - 3月 2018

!!!All Science Journal Classification (ASJC) codes

  • 神経科学(その他)
  • 免疫学
  • 免疫学および微生物学(その他)
  • 臨床神経学

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