Computational analysis of morphological and molecular features in gastric cancer tissues

Yoko Yasuda, Kazuaki Tokunaga, Tomoaki Koga, Chiyomi Sakamoto, Ilya G Goldberg, Noriko Saitoh, Mitsuyoshi Nakao

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)


Biological morphologies of cells and tissues represent their physiological and pathological conditions. The importance of quantitative assessment of morphological information has been highly recognized in clinical diagnosis and therapeutic strategies. In this study, we used a supervised machine learning algorithm wndchrm to classify hematoxylin and eosin (H&E)-stained images of human gastric cancer tissues. This analysis distinguished between noncancer and cancer tissues with different histological grades. We then classified the H&E-stained images by expression levels of cancer-associated nuclear ATF7IP/MCAF1 and membranous PD-L1 proteins using immunohistochemistry of serial sections. Interestingly, classes with low and high expressions of each protein exhibited significant morphological dissimilarity in H&E images. These results indicated that morphological features in cancer tissues are correlated with expression of specific cancer-associated proteins, suggesting the usefulness of biomolecular-based morphological classification.

ジャーナルCancer Medicine
出版ステータス印刷前の電子出版 - 2月 3 2020


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