Comparative analyses of tumour immune microenvironment between collecting duct carcinoma and fumarate hydratase-deficient renal cell carcinoma

Daisuke Kiyozawa, Kenichi Kohashi, Dai Takamatsu, Shinya Umekita, Masatoshi Eto, Mitsuru Kinjo, Kenichi Nishiyama, Kenichi Taguchi, Yumi Oshiro, Yusuke Kuboyama, Yoshinao Oda

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Aims Collecting duct carcinoma (CDC) and fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) have similar histological morphologies and both show a poor prognosis. Programmed death ligand 1 (PD-L1) inhibitor has been approved for the treatment of RCC. However, tumour-infiltrating neutrophils stimulated by interleukin-8 (IL-8) interfere with PD-L1 inhibitors. Here, we retrospectively analysed PD-L1 and IL-8 expression, and examined its relationship with infiltrating immune cells. Methods Nine cases of CDC and seven cases of FH-deficient RCC were selected. We defined PD-L1 and IL-8 expression by the Tumour Proportion Score and Combined Positive Score (CPS). We counted the numbers of CD8 +, CXCR2 +, CD11b +, CD66b + and CD33 + immune cells located in the tumour components. Results A number of CXCR2 + (p=0.0058), CD11b + (p=0.0070) and CD66b + (p=0.0067) immune cells infiltrating into CDC were significantly higher than those infiltrating into FH-deficient RCC. In CDC, PD-L1 expression was correlated with a high density of CD8 + lymphocytes (p=0.0389), but was not in FH-deficient RCC (p=0.6985). IL-8 CPS was significantly higher in CDC than in FH-deficient RCC (p=0.0069). In addition, among the CDC cases, IL-8 CPS showed significant positive correlations with CXCR2 +, CD11b + and CD66b + immune cell densities (p=0.0250, p=0.0104 and p=0.0374, respectively), whereas FH-deficient RCC showed no significant correlations between IL-8 CPS and immune cell densities. Conclusions Our results suggest the difference of each tumour microenvironment between CDC and FH-deficient RCC, and IL-8 is a potential therapeutic target for treating CDC, but not FH-deficient RCC.

本文言語英語
ページ(範囲)105-110
ページ数6
ジャーナルJournal of Clinical Pathology
77
2
DOI
出版ステータス出版済み - 11月 8 2022

!!!All Science Journal Classification (ASJC) codes

  • 病理学および法医学

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