Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma

Shinji Tanaka, Masaki Mori, Tsuyoshi Akiyoshi, Youichi Tanaka, Ken Ichi Mafune, Jack R. Wands, Keizo Sugimachi

研究成果: ジャーナルへの寄稿学術誌査読

88 被引用数 (Scopus)

抄録

Growth factor receptors transmit intracellular signals that may be important in carcinogenesis. The Grb7 protein was recently identified as a substrate of the epidermal growth factor receptor and related Her2/erbB2 receptor-linked tyrosine kinase activity. The Grb7 gene has been found to be coamplified with Her2/erbB2 in breast carcinomas. In this study, Grb7 expression was studied in 32 human esophageal cancers. A human Grb7 cDNA encoding for N-terminal amino acids was isolated and found to be 90% homologous to the murine counterpart. Although there was no amplification of the Grb7 gene in esophageal cancers, Grb7 mRNA was found to be overexpressed in 14 cancers (43.8%) but not in adjacent normal esophageal mucosa. It is noteworthy that coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 was detected in 10 esophageal carcinomas (31.3%) and was significantly related to extramucosal tumor invasion (P = 0.02), whereas such a relationship was not shown by each sole expression. These findings suggest a possible relationship of Grb7 signaling in association with expression of tyrosine kinase receptors in aggressive human esophageal cancer.

本文言語英語
ページ(範囲)28-31
ページ数4
ジャーナルCancer Research
57
1
出版ステータス出版済み - 1月 18 1997

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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