Circular dichroism readout of sugar recognition in the cleft of a fused-pyridine receptor

Shun Ichi Tamaru, Seiji Shinkai, Alisher B. Khasanov, Thomas W. Bell

研究成果: ジャーナルへの寄稿学術誌査読

38 被引用数 (Scopus)

抄録

Dicarboxamide host 2 forms 1:1 complexes with n-octyl pyranosides derived from D-glucose, D-mannose, D-galactose, D-fucose, D-lyxose, and D-arabinose. Association constants (Ka) in the range of 77-940 M-1 were measured in chloroform by means of induced circular dichroism and fluorescence spectroscopy. Variations in Ka values correspond qualitatively to expected differences in hydrogen-bonding abilities of guest hydroxyl groups. Induced circular dichroism effects for complexes of saccharides bearing equatorial 3-OH, 4-OH, and 6-OH groups show that the host chromophore is twisted in a P-helical conformation. A structural model is proposed that is also consistent with the results of previous studies involving complexation of dicarboxylic acid 1 with cationic saccharides in methanol.

本文言語英語
ページ(範囲)4972-4976
ページ数5
ジャーナルProceedings of the National Academy of Sciences of the United States of America
99
8
DOI
出版ステータス出版済み - 4月 16 2002
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 一般

フィンガープリント

「Circular dichroism readout of sugar recognition in the cleft of a fused-pyridine receptor」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル