Characterization of nanoparticle permeability on a membrane-integrated microfluidic device

N. Sasaki, M. Tatanou, Y. Anraku, A. Kishimura, K. Kataoka, K. Sato

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

4 被引用数 (Scopus)

抄録

We present a microfluidic platform to characterize nanoparticle permeability, which determines the efficiency of nanoparticle-based drug delivery to tumors. We integrated porous membranes that mimic tumor vascular walls into microfluidic devices. Permeation of the nanoparticles through the membranes was studied under control of transmembrane flow, which corresponds to outward flow from blood vessels to tumors in vivo. The obtained results agreed with a theoretical model considering the effect of particle/pore size ratio on the permeation. These results indicate that the device can be a simple model to estimate the permeability of the nanoparticles.

本文言語英語
ホスト出版物のタイトル17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
出版社Chemical and Biological Microsystems Society
ページ1818-1820
ページ数3
ISBN(印刷版)9781632666246
出版ステータス出版済み - 2013
イベント17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, ドイツ
継続期間: 10月 27 201310月 31 2013

出版物シリーズ

名前17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
3

その他

その他17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
国/地域ドイツ
CityFreiburg
Period10/27/1310/31/13

!!!All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング

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