Characterization of magnetic markers for liquid-phase detection of biological targets

Yuichi Higuchi, Shinobu Uchida, Anwarul Kabir Bhuiya, Takashi Yoshida, Keiji Enpuku

研究成果: ジャーナルへの寄稿学術誌査読

12 被引用数 (Scopus)

抄録

We characterized the properties of magnetic markers for liquid phase immunoassays using Brownian relaxation. Since magnetic markers are usually composed of aggregated magnetic nanoparticles, their properties are significantly affected by the degree of aggregation. Through the analysis of magnetization (M-H) and AC susceptibility measurements, we obtained the distribution of the magnetic moment m and the Neel relaxation time τN of the aggregated particles included in the markers. We also determined the relationship between m and τN. From the obtained result, we could classify the particles into three types: Type-1 particles with very small m and very short τN , Type-2 particles with medium values of m and τN, and Type-3 particles with large m and very long τN. The proportion of these three types of particles included in the marker was also evaluated. We show that Type-3 particles and some Type-2 particles with τ N > τB are primarily responsible for the observed signal in the liquid phase immunoassay using Brownian relaxation, where τB is the Brownian relaxation time. The obtained results are useful for evaluating suitable markers for liquid phase immunoassays using Brownian relaxation.

本文言語英語
論文番号6558894
ページ(範囲)3456-3459
ページ数4
ジャーナルIEEE Transactions on Magnetics
49
7
DOI
出版ステータス出版済み - 2013

!!!All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 電子工学および電気工学

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