Characterization of leukaemic basophil progenitors from chronic myelogenous leukaemia

Takanori Teshima, Seiji Kondo, Mine Harada, Tsunefumi Shibuya, Takashi Okamura, Yuichi Tamari, Nobuhiro Kimura, Koichi Akashi, Seiichi Okamura, Yoshiyuki Niho

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

Summary We describe the unique characteristics of leukaemic basophils from a patient with chronic myelogenous leukaemia (CML). The leukaemic cells were immature basophil‐like blasts and expressed CD4, CD7 and HLA‐DR in addition to CD13 and CD33. Both immunoglobulin and T cell receptor genes were retained in germline configurations. Interleukin‐1 (IL‐1) or granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) as well as IL‐3 or IL‐4 enhanced the proliferation and differentiation of leukaemic cells and only basophils were generated from in vitro culture. These results suggest that basophil progenitors expressing CD4, CD7 and HLA‐DR may be involved in the development of basophilic crisis of CML and that both IL‐1 and GM‐CSF may act on basophil progenitors as well as IL‐3 or IL‐4.

本文言語英語
ページ(範囲)55-59
ページ数5
ジャーナルBritish Journal of Haematology
78
1
DOI
出版ステータス出版済み - 5月 1991

!!!All Science Journal Classification (ASJC) codes

  • 血液学

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