TY - JOUR
T1 - Cerebral muscarinic acetylcholinergic receptor measurement in Alzheimer's disease patients on 11C-N-methyl-4-piperidyl benzilate - Comparison with cerebral blood flow and cerebral glucose metabolism
AU - Yoshida, Tsuyoshi
AU - Kuwabara, Yasuo
AU - Ichiya, Yuichi
AU - Sasaki, Masayuki
AU - Fukumura, Toshimitsu
AU - Ichimiya, Atsushi
AU - Takita, Masashi
AU - Ogomori, Koji
AU - Masuda, Kouji
N1 - Funding Information:
The authors thank Dr. Osamu Inoue of Osaka University and Dr. Kazutoshi Suzuki of the National Institute of Radiological Sciences for their pharmaceutical advice and we also thank Dr. Kouhei Akazawa of Department of Medical Informatic for statistical advice and Dr. Brian T. Quinn of Department of Literature for editorial assistance. This work was partly supported by Grant No. 6B-2 and a No. 94A-2401-4 from the Japanese Ministry of Health and Welfare, and a Grant-in-Aid (05670781) for Scientific Research from the Japanese Ministry of Education, Science and Culture.
PY - 1998/2
Y1 - 1998/2
N2 - We studied the cerebral muscarinic acetylcholinergic receptor (mACh-R) by means of 11C-N-methyl-4-piperidyl benzilate (11C-NMPB) and positron emission tomography (PET) in Alzheimer's disease (AD) cases, and the findings were compared with the cerebral blood flow (CBF) and the glucose metabolism (CMRGlc) to evaluate the relationship between the mACh-R and the CBF or the CMRGlc. The subjects consisted of 18 patients with AD and 18 age and sex matched normal volunteers. The patients were clinically diagnosed according to the criteria of the NINDS-ADRDA as having 'probable AD' and were thus classified into two groups (mild and moderate AD) according to the severity of dementia determined by DSM-III-R. The CBF was measured by (99m)TcHMPAO SPECT, and the CMRGlc was measured by 18FDG PET. The 11C-NMPB uptake was evaluated by the graphical method and the ratio method (ROIs/Cerebellum). A significant mAChR decrease and more severe CMRGlc decrease in the conical region was seen in mild and moderate AD. The decrease in the CBF was not as obvious as that in the mACh-R and the CMRGlc. Our study thus suggested that the mACh-R decreased in patients with AD, and that the 18FDG PET was the most sensitive method for detecting the degenerative regions in patients with AD.
AB - We studied the cerebral muscarinic acetylcholinergic receptor (mACh-R) by means of 11C-N-methyl-4-piperidyl benzilate (11C-NMPB) and positron emission tomography (PET) in Alzheimer's disease (AD) cases, and the findings were compared with the cerebral blood flow (CBF) and the glucose metabolism (CMRGlc) to evaluate the relationship between the mACh-R and the CBF or the CMRGlc. The subjects consisted of 18 patients with AD and 18 age and sex matched normal volunteers. The patients were clinically diagnosed according to the criteria of the NINDS-ADRDA as having 'probable AD' and were thus classified into two groups (mild and moderate AD) according to the severity of dementia determined by DSM-III-R. The CBF was measured by (99m)TcHMPAO SPECT, and the CMRGlc was measured by 18FDG PET. The 11C-NMPB uptake was evaluated by the graphical method and the ratio method (ROIs/Cerebellum). A significant mAChR decrease and more severe CMRGlc decrease in the conical region was seen in mild and moderate AD. The decrease in the CBF was not as obvious as that in the mACh-R and the CMRGlc. Our study thus suggested that the mACh-R decreased in patients with AD, and that the 18FDG PET was the most sensitive method for detecting the degenerative regions in patients with AD.
UR - https://www.scopus.com/pages/publications/0031953757
UR - https://www.scopus.com/pages/publications/0031953757#tab=citedBy
U2 - 10.1007/BF03165414
DO - 10.1007/BF03165414
M3 - Article
C2 - 9559960
AN - SCOPUS:0031953757
SN - 0914-7187
VL - 12
SP - 35
EP - 42
JO - Annals of Nuclear Medicine
JF - Annals of Nuclear Medicine
IS - 1
ER -