Catabolic effects of muramyl dipeptide on rabbit chondrocytes

Tetsuro Ikebe, Hideaki Iribe, Masato Hirata, Fumi Yanaga, Toshitaka Koga

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

Muramyl dipeptide, an essential structure for the diverse biologic activities of bacterial cell wall peptidoglycan, inhibited the synthesis of glycosaminoglycan/proteoglycan in cultured rabbit costal chondrocytes in a dose‐dependent manner. Muramyl dipeptide, as well as lipopolysaccharide and interleukin‐1α, also enhanced the release of 35S‐sulfate—prelabeled glycosaminoglycan/proteoglycan from the cell layer, which seems to reflect, at least partially, the increasing degradation of glycosaminoglycan/proteoglycan. Five synthetic analogs of muramyl dipeptide known to be adjuvant active or adjuvant inactive were tested for their potential to inhibit synthesis of glycosaminoglycan/proteoglycan and to enhance the release of glycosaminoglycan/proteoglycan in chondrocytes. The structural dependence of these synthetic analogs on chondrocytes was found to parallel that of immunoadjuvant activity. These results suggest that muramyl dipeptide is a potent mediator of catabolism in chondrocytes.

本文言語英語
ページ(範囲)1801-1806
ページ数6
ジャーナルArthritis & Rheumatism
33
12
DOI
出版ステータス出版済み - 12月 1990

!!!All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • リウマチ学
  • 免疫学
  • 薬理学(医学)

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