TY - JOUR
T1 - Case Report
T2 - Rotavirus Vaccination and Severe Combined Immunodeficiency in Japan
AU - Tanita, Kay
AU - Kawamura, Yoshiki
AU - Miura, Hiroki
AU - Mitsuiki, Noriko
AU - Tomoda, Takahiro
AU - Inoue, Kento
AU - Iguchi, Akihiro
AU - Yamada, Masafumi
AU - Yoshida, Taro
AU - Muramatsu, Hideki
AU - Tada, Norimasa
AU - Matsui, Toshihiro
AU - Kato, Motohiro
AU - Eguchi, Katsuhide
AU - Ishimura, Masataka
AU - Ohga, Shouichi
AU - Imai, Kohsuke
AU - Morio, Tomohiro
AU - Yoshikawa, Tetsushi
AU - Kanegane, Hirokazu
N1 - Funding Information:
This study was partly funded by Takeda Science Foundation.
Publisher Copyright:
Copyright © 2022 Tanita, Kawamura, Miura, Mitsuiki, Tomoda, Inoue, Iguchi, Yamada, Yoshida, Muramatsu, Tada, Matsui, Kato, Eguchi, Ishimura, Ohga, Imai, Morio, Yoshikawa and Kanegane.
PY - 2022/2/23
Y1 - 2022/2/23
N2 - Severe combined immunodeficiency (SCID) is an inborn error of immunity that occurs in approximately 1 in 50,000 births, mainly due to impaired lymphocyte differentiation. Without curative treatment, such as hematopoietic cell transplantation (HCT) or gene therapy, severe infection in the first year of life could make this condition fatal. The results of HCT are poor when patients have active infections, thus requiring early diagnosis before onset of infection. In five cases of SCID diagnosed in Japan, the oral rotavirus vaccine had been administered before diagnosis. In this study, we demonstrated that the rotavirus from their stools was a vaccine-derived strain. In some cases, severe gastroenteritis triggered the diagnosis of SCID. However, newborn screening for SCID is available before the first rotavirus vaccination using assays for the detection of T-cell receptor excision circles (TRECs). Therefore, to improve the prognosis of patients with SCID in Japan, we should establish a screening system of TRECs for newborns throughout Japan.
AB - Severe combined immunodeficiency (SCID) is an inborn error of immunity that occurs in approximately 1 in 50,000 births, mainly due to impaired lymphocyte differentiation. Without curative treatment, such as hematopoietic cell transplantation (HCT) or gene therapy, severe infection in the first year of life could make this condition fatal. The results of HCT are poor when patients have active infections, thus requiring early diagnosis before onset of infection. In five cases of SCID diagnosed in Japan, the oral rotavirus vaccine had been administered before diagnosis. In this study, we demonstrated that the rotavirus from their stools was a vaccine-derived strain. In some cases, severe gastroenteritis triggered the diagnosis of SCID. However, newborn screening for SCID is available before the first rotavirus vaccination using assays for the detection of T-cell receptor excision circles (TRECs). Therefore, to improve the prognosis of patients with SCID in Japan, we should establish a screening system of TRECs for newborns throughout Japan.
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UR - http://www.scopus.com/inward/citedby.url?scp=85126265462&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2022.786375
DO - 10.3389/fimmu.2022.786375
M3 - Article
C2 - 35281013
AN - SCOPUS:85126265462
SN - 1664-3224
VL - 13
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 786375
ER -
