Cardiopulmonary exercise testing for patients with anorexia nervosa: a case–control study

Makoto Yamashita, Keisuke Kawai, Kenta Toda, Chie Aso, Takafumi Suematsu, Hiroaki Yokoyama, Tomokazu Hata, Shu Takakura, Nobuyuki Sudo

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)


Purpose: Patients with anorexia nervosa (AN) require appropriate nutrient therapy and physical activity management. Eating disorder treatment guidelines do not include safe, evidence-based intensity criteria for exercise. This study used cardiopulmonary exercise testing (CPX) to evaluate the exercise tolerance of patients with AN. Methods: CPX was performed with 14 female patients with AN admitted to a specialized eating disorder unit between 2015 and 2019. Their anaerobic threshold (AT) was determined by assessing their exercise tolerance using CPX and compared with 14 healthy controls (HC). The metabolic equivalents (AT-METS) were compared when AT was reached. We examined factors related to AT (AN-AT) in the AN group, including age, body mass index (BMI), previous lowest weight, minimum BMI, past duration of BMI < 15, exercise history, and ΔHR (heart rate at the AT—resting heart rate). Results: The AT of the AN group (BMI: 15.7 [Mean] ± 1.8 standard deviation [SD]) was significantly lower than that of the HC group (BMI: 19.7 ± 1.8) (AN: 10.0 ± 1.8 vs. HC: 15.2 ± 3.0 ml/kg/min, P < 0.001). AT-METS was also significantly lower in the AN group than in the HC group (AN: 2.9 ± 0.52 vs. HC: 4.4 ± 0.91, P < 0.001). AN-AT was highly influenced by ΔHR. Conclusions: This study showed that AT and AT-METS were lower in patients with AN than in HC. Patients with AN should be prescribed light-intensity aerobic exercise, and the current findings may help develop future physical management guidelines for patients with AN. Level of evidence: III: Evidence obtained from case–control analytic studies.

ジャーナルEating and Weight Disorders
出版ステータス出版済み - 12月 2022

!!!All Science Journal Classification (ASJC) codes

  • 臨床心理学
  • 精神医学および精神衛生


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