Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients

Nobutoshi Kawamura; Hua Piao; Motozumi Minohara; Takuya Matsushita; Susumu Kusunoki; Hiroshi Matsumoto; Kazuhiro Ikenaka; Yoshimitsu Mizunoe; Jun ichi Kira

doi:10.1016/j.jneuroim.2011.09.004

Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients

Nobutoshi Kawamura
, Hua Piao
, Motozumi Minohara
, Takuya Matsushita
, Susumu Kusunoki
, Hiroshi Matsumoto
, Kazuhiro Ikenaka
, Yoshimitsu Mizunoe
, Jun ichi Kira

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

4 被引用数 (Scopus)

抄録

Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barré syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.

本文言語	英語
ページ（範囲）	74-78
ページ数	5
ジャーナル	Journal of Neuroimmunology
巻	240-241
DOI	https://doi.org/10.1016/j.jneuroim.2011.09.004
出版ステータス	出版済み - 12月 15 2011

!!!All Science Journal Classification (ASJC) codes

免疫アレルギー学
免疫学
神経学
臨床神経学

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10.1016/j.jneuroim.2011.09.004

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@article{f88c47ecc61a486ca95ea1f0fd1760aa,

title = "Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barr{\'e} syndrome patients",

abstract = "Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barr{\'e} syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8\% and 15/24, 62.5\%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.",

author = "Nobutoshi Kawamura and Hua Piao and Motozumi Minohara and Takuya Matsushita and Susumu Kusunoki and Hiroshi Matsumoto and Kazuhiro Ikenaka and Yoshimitsu Mizunoe and Kira, \{Jun ichi\}",

note = "Funding Information: This work was supported in part by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan , a Neuroimmunological Disease Research Committee grant from the Ministry of Health, Labour and Welfare of Japan and a grant for Research on Brain Science.",

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AU - Kawamura, Nobutoshi

AU - Piao, Hua

AU - Minohara, Motozumi

AU - Matsushita, Takuya

AU - Kusunoki, Susumu

AU - Matsumoto, Hiroshi

AU - Ikenaka, Kazuhiro

AU - Mizunoe, Yoshimitsu

AU - Kira, Jun ichi

N1 - Funding Information: This work was supported in part by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan , a Neuroimmunological Disease Research Committee grant from the Ministry of Health, Labour and Welfare of Japan and a grant for Research on Brain Science.

PY - 2011/12/15

Y1 - 2011/12/15

N2 - Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barré syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.

AB - Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barré syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.

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M3 - Article

C2 - 21996079

AN - SCOPUS:83555176383

SN - 0165-5728

VL - 240-241

SP - 74

EP - 78

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients

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!!!All Science Journal Classification (ASJC) codes

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