Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Soichiro Yamanaka; Hidenori Nishihara; Hidehiro Toh; Luis Augusto Eijy Nagai; Kosuke Hashimoto; Sung Joon Park; Aoi Shibuya; Ana Maria Suzuki; Yujiro Tanaka; Kenta Nakai; Piero Carninci; Hiroyuki Sasaki; Haruhiko Siomi

doi:10.1016/j.devcel.2019.07.023

Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Soichiro Yamanaka
, Hidenori Nishihara
, Hidehiro Toh
, Luis Augusto Eijy Nagai
, Kosuke Hashimoto
, Sung Joon Park
, Aoi Shibuya
, Ana Maria Suzuki
, Yujiro Tanaka
, Kenta Nakai
, Piero Carninci
, Hiroyuki Sasaki
, Haruhiko Siomi

分子機能制御学部門

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

38 被引用数 (Scopus)

抄録

Genome-wide de novo DNA methylation occurs in mouse gonocytes, arrested male embryonic germ cells. However, how the methylome gets established in the genome of arrested cells remains unexplored. Yamanaka et al. report that multiple chromatin reprogramming pathways allow the access of methyltransferases to DNA in gonocytes.

本文言語	英語
ページ（範囲）	21-34.e5
ジャーナル	Developmental Cell
巻	51
号	1
DOI	https://doi.org/10.1016/j.devcel.2019.07.023
出版ステータス	出版済み - 10月 7 2019

!!!All Science Journal Classification (ASJC) codes

分子生物学
生化学、遺伝学、分子生物学一般
発生生物学
細胞生物学

文献へのアクセス

10.1016/j.devcel.2019.07.023

他のファイルとリンク

引用スタイル

@article{312d7bd871684bd19071ef3cb8bf9cac,

title = "Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation",

abstract = "Genome-wide de novo DNA methylation occurs in mouse gonocytes, arrested male embryonic germ cells. However, how the methylome gets established in the genome of arrested cells remains unexplored. Yamanaka et al. report that multiple chromatin reprogramming pathways allow the access of methyltransferases to DNA in gonocytes.",

keywords = "ATAC-seq, de novo DNA methylation, gene cluster, gene desert, gonocyte, transposon",

author = "Soichiro Yamanaka and Hidenori Nishihara and Hidehiro Toh and \{Eijy Nagai\}, \{Luis Augusto\} and Kosuke Hashimoto and Park, \{Sung Joon\} and Aoi Shibuya and Suzuki, \{Ana Maria\} and Yujiro Tanaka and Kenta Nakai and Piero Carninci and Hiroyuki Sasaki and Haruhiko Siomi",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = oct,

day = "7",

doi = "10.1016/j.devcel.2019.07.023",

language = "English",

volume = "51",

pages = "21--34.e5",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

AU - Yamanaka, Soichiro

AU - Nishihara, Hidenori

AU - Toh, Hidehiro

AU - Eijy Nagai, Luis Augusto

AU - Hashimoto, Kosuke

AU - Park, Sung Joon

AU - Shibuya, Aoi

AU - Suzuki, Ana Maria

AU - Tanaka, Yujiro

AU - Nakai, Kenta

AU - Carninci, Piero

AU - Sasaki, Hiroyuki

AU - Siomi, Haruhiko

PY - 2019/10/7

Y1 - 2019/10/7

N2 - Genome-wide de novo DNA methylation occurs in mouse gonocytes, arrested male embryonic germ cells. However, how the methylome gets established in the genome of arrested cells remains unexplored. Yamanaka et al. report that multiple chromatin reprogramming pathways allow the access of methyltransferases to DNA in gonocytes.

AB - Genome-wide de novo DNA methylation occurs in mouse gonocytes, arrested male embryonic germ cells. However, how the methylome gets established in the genome of arrested cells remains unexplored. Yamanaka et al. report that multiple chromatin reprogramming pathways allow the access of methyltransferases to DNA in gonocytes.

KW - ATAC-seq

KW - de novo DNA methylation

KW - gene cluster

KW - gene desert

KW - gonocyte

KW - transposon

UR - https://www.scopus.com/pages/publications/85072703324

UR - https://www.scopus.com/pages/publications/85072703324#tab=citedBy

U2 - 10.1016/j.devcel.2019.07.023

DO - 10.1016/j.devcel.2019.07.023

M3 - Article

C2 - 31474564

AN - SCOPUS:85072703324

SN - 1534-5807

VL - 51

SP - 21-34.e5

JO - Developmental Cell

JF - Developmental Cell

IS - 1

ER -

Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

抄録

!!!All Science Journal Classification (ASJC) codes

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル