Branching Reaction in Melanogenesis: The Effect of Intramolecular Cyclization on Thiol Binding

Ryo Kishida, Hideaki Kasai, Susan Meñez Aspera, Ryan Lacdao Arevalo, Hiroshi Nakanishi

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

With the aid of density functional theory-based first principles calculations, we investigated energetics and electronic structure changes in reactions involving dopaquinone to give insights into the branching behaviors in melanogenesis. The reactions we investigated are the intramolecular cyclization and thiol binding, which are competing with each other. It was found that, in order to accomplish thiol binding, charge transfer of around one electron from thiol to dopaquinone occurs. Furthermore, intramolecular cyclization of dopaquinone increases the lowest unnoccupied molecular orbital level substantially. This result clearly shows prevention of the binding of thiol by intramolecular cyclization.

本文言語英語
ページ(範囲)3784-3788
ページ数5
ジャーナルJournal of Electronic Materials
46
6
DOI
出版ステータス出版済み - 6月 1 2017
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 凝縮系物理学
  • 電子工学および電気工学
  • 材料化学

フィンガープリント

「Branching Reaction in Melanogenesis: The Effect of Intramolecular Cyclization on Thiol Binding」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル