TY - JOUR
T1 - Brain network alterations in anorexia Nervosa
T2 - A Multi-Center structural connectivity study
AU - Kanzawa, Jun
AU - Kurokawa, Ryo
AU - Takamura, Tsunehiko
AU - Nohara, Nobuhiro
AU - Kamiya, Kouhei
AU - Moriguchi, Yoshiya
AU - Sato, Yasuhiro
AU - Hamamoto, Yumi
AU - Shoji, Tomotaka
AU - Muratsubaki, Tomohiko
AU - Sugiura, Motoaki
AU - Fukudo, Shin
AU - Hirano, Yoshiyuki
AU - Sudo, Yusuke
AU - Kamashita, Rio
AU - Hamatani, Sayo
AU - Numata, Noriko
AU - Matsumoto, Koji
AU - Shimizu, Eiji
AU - Kodama, Naoki
AU - Kakeda, Shingo
AU - Takahashi, Masatoshi
AU - Ide, Satoru
AU - Okada, Kazumasa
AU - Takakura, Shu
AU - Gondo, Motoharu
AU - Yoshihara, Kazufumi
AU - Isobe, Masanori
AU - Tose, Keima
AU - Noda, Tomomi
AU - Mishima, Ryo
AU - Kawabata, Michiko
AU - Noma, Shun'ichi
AU - Murai, Toshiya
AU - Yoshiuchi, Kazuhiro
AU - Sekiguchi, Atsushi
AU - Abe, Osamu
N1 - Publisher Copyright:
© 2025 The Author(s)
PY - 2025/1
Y1 - 2025/1
N2 - Anorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained tractography, and spherical deconvolution informed filtering of tractograms to analyze brain network alterations in AN. Diffusion MRI data from 81 AN patients and 98 healthy controls were obtained. The structural brain connectome was constructed based on nodes set in 84 brain regions, and graph theory analysis was conducted. Results showed that AN patients exhibited significantly higher clustering coefficient and local efficiency in several brain regions, including the left fusiform gyrus, bilateral orbitofrontal cortex, right entorhinal cortex, right lateral occipital gyrus, right superior temporal gyrus, and right insula. A trend towards higher global efficiency and small-worldness was also observed in AN patients, although not statistically significant. These findings suggest increased local connectivity and efficiency within regions associated with behavioral rigidity, emotional regulation, and disturbed body image among AN patients. This study contributes to the understanding of the neurological basis of AN by highlighting structural connectivity alterations in specific brain regions.
AB - Anorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained tractography, and spherical deconvolution informed filtering of tractograms to analyze brain network alterations in AN. Diffusion MRI data from 81 AN patients and 98 healthy controls were obtained. The structural brain connectome was constructed based on nodes set in 84 brain regions, and graph theory analysis was conducted. Results showed that AN patients exhibited significantly higher clustering coefficient and local efficiency in several brain regions, including the left fusiform gyrus, bilateral orbitofrontal cortex, right entorhinal cortex, right lateral occipital gyrus, right superior temporal gyrus, and right insula. A trend towards higher global efficiency and small-worldness was also observed in AN patients, although not statistically significant. These findings suggest increased local connectivity and efficiency within regions associated with behavioral rigidity, emotional regulation, and disturbed body image among AN patients. This study contributes to the understanding of the neurological basis of AN by highlighting structural connectivity alterations in specific brain regions.
KW - Anorexia Nervosa (AN)
KW - Diffusion MRI
KW - Graph Theory
KW - Single-Shell 3-Tissue Constrained Spherical Deconvolution (SS3T-CSD)
KW - Structural Connectivity
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U2 - 10.1016/j.nicl.2025.103737
DO - 10.1016/j.nicl.2025.103737
M3 - Article
C2 - 39892053
AN - SCOPUS:85216596382
SN - 2213-1582
VL - 45
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 103737
ER -