TY - JOUR
T1 - Biofunctionality of self-assembled nanolayers composed of cellulosic polymers
AU - Yokota, Shingo
AU - Kitaoka, Takuya
AU - Wariishi, Hiroyuki
N1 - Funding Information:
This research was supported by a Research Fellowship from the Japan Society for the Promotion of Science for Young Scientists (S.Y.) and by a Grant-in-Aid for Young Scientists (No. 17688008) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan (T.K.).
PY - 2008/11/4
Y1 - 2008/11/4
N2 - Biofunctional cellulosic interfaces were successfully designed via the self-assembly of cellulose and its derivatives whose reducing ends were selectively modified with thiosemicarbazide. The biological functions of cellulosic self-assembled monolayers (SAMs) formed on a gold surface were investigated using rat liver cells. The cells proliferated well on the cellulose SAM (cellulose I) and methylcellulose SAM, while almost no cells adhered to the regenerated cellulose film (cellulose II) and hydroxyethylcellulose SAM. In the initial cell adhesion, rat liver cells were moderately attached on the cellulose SAM even in serum-free culture, possibly suggesting specific interactions between cells and cellulose SAM with unique surface morphology. The architectural design of cellulosic nanolayers via peculiar vectorial chain immobilization is expected to provide new information for the functional development of structural polysaccharide-based biointerfaces.
AB - Biofunctional cellulosic interfaces were successfully designed via the self-assembly of cellulose and its derivatives whose reducing ends were selectively modified with thiosemicarbazide. The biological functions of cellulosic self-assembled monolayers (SAMs) formed on a gold surface were investigated using rat liver cells. The cells proliferated well on the cellulose SAM (cellulose I) and methylcellulose SAM, while almost no cells adhered to the regenerated cellulose film (cellulose II) and hydroxyethylcellulose SAM. In the initial cell adhesion, rat liver cells were moderately attached on the cellulose SAM even in serum-free culture, possibly suggesting specific interactions between cells and cellulose SAM with unique surface morphology. The architectural design of cellulosic nanolayers via peculiar vectorial chain immobilization is expected to provide new information for the functional development of structural polysaccharide-based biointerfaces.
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U2 - 10.1016/j.carbpol.2008.04.027
DO - 10.1016/j.carbpol.2008.04.027
M3 - Article
AN - SCOPUS:49149095322
SN - 0144-8617
VL - 74
SP - 666
EP - 672
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
IS - 3
ER -