Bio-inspired Water Structure: Intermediate Water in Hydrated Bio-polymers and Synthetic Bio-compatible Polymers

There are numerous parameters of polymeric biomaterials that can affect protein adsorption and cell adhesion. The mechanisms responsible for the polymer-protein-cell interactions at the molecular level have not been clearly demonstrated, although many theoretical and experimental efforts have been made to understand these mechanisms. Water interactions have been recognized as fundamental for protein and cell response to contact with polymers. This chapter focuses on the interfacial water at the polymer-protein-cell interfaces and specific water structure in hydrated bio-polymers and bio-inspired water in hydrated synthetic polymers. Additionally, it highlights recent developments in the use of bio-compatible polymeric biomaterials for medical devices and provides an overview of the progress made in the design of multifunctional biomedical polymers by controlling the bio-inspired water structure through precision polymer synthesis.