Baroreflex failure and beat-to-beat blood pressure variation

Takuya Kishi

    研究成果: ジャーナルへの寄稿総説査読

    29 被引用数 (Scopus)

    抄録

    Hypertension has strong adverse effects on cardiovascular diseases, and increased blood pressure (BP) variability (BPV) is closely associated with the development of hypertensive organ injuries and the occurrence of cardiovascular diseases. Similar to other forms of BPV, short-term beat-to-beat BPV has also been established as a risk factor for cardiovascular diseases. Baroreflex failure is the major mechanism involved in the pathophysiology of short-term beat-to-beat BPV. Previous clinical and animal studies have demonstrated that baroreflex failure disrupted beat-to-beat BPV and hypertensive organ damage. Moreover, short-term beat-to-beat BPV was an independent determinant of vascular elasticity. Although, the clinical measurement tools and therapeutics for beat-to-beat BPV are not sufficient, we should consider that large beat-to-beat BPV is an important risk factor for cardiovascular diseases in patients with hypertension.

    本文言語英語
    ページ(範囲)547-552
    ページ数6
    ジャーナルHypertension Research
    41
    8
    DOI
    出版ステータス出版済み - 8月 1 2018

    !!!All Science Journal Classification (ASJC) codes

    • 内科学
    • 生理学
    • 循環器および心血管医学

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