TY - JOUR
T1 - Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer
AU - Takeshita, Masafumi
AU - Koga, Takaomi
AU - Takayama, Koichi
AU - Ijichi, Kayo
AU - Yano, Tokujiro
AU - Maehara, Yoshihiko
AU - Nakanishi, Yoichi
AU - Sueishi, Katsuo
N1 - Funding Information:
The authors thank Mr. Hiroshi Fujii for their excellent technical assistance, Mr. Noriya Taki for his technical statistical advice. This work was supported in part by a Grant in Aid from the Japanese Ministry of Education, Culture, Sports, Science, and Technology , Tokyo, Japan (# 16209012 , # 17590305 , # 1920912 , and # 22590316 ).
PY - 2013/4
Y1 - 2013/4
N2 - Aurora-B is a key regulator of mitosis, and the overexpression has been detected in a variety of solid tumors. The Aurora-B overexpression has been suggested to correlate with clinical aggressiveness and aneuploidy in vitro, however, the frequency of overexpression of Aurora-B protein, the association with clinicopathologic parameters and aneuploidy remain poorly defined in non-small-cell lung cancer (NSCLC). Using 157 surgical specimens of human NSCLC, we here show that overexpression of Aurora-B proteins are significantly correlated with aneuploidy and poor outcomes in NSCLC. We examined immunohistochemical protein expression of Aurora-B, and DNA ploidy by laser scanning cytometry in 157 NSCLC cases. Aurora-B overexpression was found in 83 cases (53%) of NSCLC, and was significantly correlated with vascular invasion (p=0.012), poor differentiation (p<0.001), larger tumor size (p=0.010) and lymph node metastasis (p=0.05) and poor prognosis (p=0.011). Aneuploidy was found in 87 cases (57%), and was significantly correlated with Aurora-B overexpression (p=0.0065). Logistic multivariate analysis revealed overexpression of Aurora-B protein to be significant risk factors for aneuploidy compared with other factors. These results indicate that Aurora-B overexpression may contribute to malignant potential and increased aneuploidy in NSCLC. Thus, Aurora-B may serve as a new therapeutic target in against patients with NSCLC, although further studies will be necessary.
AB - Aurora-B is a key regulator of mitosis, and the overexpression has been detected in a variety of solid tumors. The Aurora-B overexpression has been suggested to correlate with clinical aggressiveness and aneuploidy in vitro, however, the frequency of overexpression of Aurora-B protein, the association with clinicopathologic parameters and aneuploidy remain poorly defined in non-small-cell lung cancer (NSCLC). Using 157 surgical specimens of human NSCLC, we here show that overexpression of Aurora-B proteins are significantly correlated with aneuploidy and poor outcomes in NSCLC. We examined immunohistochemical protein expression of Aurora-B, and DNA ploidy by laser scanning cytometry in 157 NSCLC cases. Aurora-B overexpression was found in 83 cases (53%) of NSCLC, and was significantly correlated with vascular invasion (p=0.012), poor differentiation (p<0.001), larger tumor size (p=0.010) and lymph node metastasis (p=0.05) and poor prognosis (p=0.011). Aneuploidy was found in 87 cases (57%), and was significantly correlated with Aurora-B overexpression (p=0.0065). Logistic multivariate analysis revealed overexpression of Aurora-B protein to be significant risk factors for aneuploidy compared with other factors. These results indicate that Aurora-B overexpression may contribute to malignant potential and increased aneuploidy in NSCLC. Thus, Aurora-B may serve as a new therapeutic target in against patients with NSCLC, although further studies will be necessary.
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U2 - 10.1016/j.lungcan.2012.12.018
DO - 10.1016/j.lungcan.2012.12.018
M3 - Article
C2 - 23313006
AN - SCOPUS:84875267461
SN - 0169-5002
VL - 80
SP - 85
EP - 90
JO - Lung Cancer
JF - Lung Cancer
IS - 1
ER -
