TY - JOUR
T1 - Augmented excretion of procathepsin L of a fos-transferred highly metastatic rat cell line
AU - Taniguchi, Shun'ichiro
AU - Nishimura, Yukio
AU - Takahashi, Takeshi
AU - Baba, Tsuneo
AU - Kato, Keitaro
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1990/4/30
Y1 - 1990/4/30
N2 - We previously reported that v-fos transfer to a src-transformed rat 3Y1 cell line (SR-3Y1-2) enhanced lung metastasis accompanied with an increase in invasiveness. When analyzing factors relating to the high invasiveness, with special reference to typical lysosomal proteases (cathepsins), involving degradation of stroma, we found that the excretion of procathepsin L was significantly larger in the fos-transferred highly metastatic cell line (fos-SR-3Y1-202) than that in the recipient cell lines. The cathepsin D-induced enzyme activity of the excreted procathepsin L in fos-SR-3Y1-202 was about 4 and 13 fold that of SR-3Y1-2 and 3Y1, respectively. The increase in the excretion of procathepsin L from fos-SR-3Y1-202 may play a role in the high invasiveness induced by transfer with the v-fos oncogene.
AB - We previously reported that v-fos transfer to a src-transformed rat 3Y1 cell line (SR-3Y1-2) enhanced lung metastasis accompanied with an increase in invasiveness. When analyzing factors relating to the high invasiveness, with special reference to typical lysosomal proteases (cathepsins), involving degradation of stroma, we found that the excretion of procathepsin L was significantly larger in the fos-transferred highly metastatic cell line (fos-SR-3Y1-202) than that in the recipient cell lines. The cathepsin D-induced enzyme activity of the excreted procathepsin L in fos-SR-3Y1-202 was about 4 and 13 fold that of SR-3Y1-2 and 3Y1, respectively. The increase in the excretion of procathepsin L from fos-SR-3Y1-202 may play a role in the high invasiveness induced by transfer with the v-fos oncogene.
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U2 - 10.1016/0006-291X(90)92352-Z
DO - 10.1016/0006-291X(90)92352-Z
M3 - Article
C2 - 2185753
AN - SCOPUS:0025306738
SN - 0006-291X
VL - 168
SP - 520
EP - 526
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -