Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population

Shota Ikeda, Keisuke Shinohara, Koshiro Tagawa, takeshi tohyama, Junji Kishimoto, Masaya Kazurayama, Shinji Tanaka, Masamitsu Yamaizumi, Hirokazu Nagayoshi, Kensuke Toyama, Shoji Matsushima, Hiroyuki Tsutsui, Shintaro Kinugawa

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Electrocardiographic left ventricular hypertrophy (LVH) could predict adverse renal outcomes in patients with hypertension. This study aimed to investigate the association between electrocardiographic LVH and future decline in renal function in the general population using a dataset of population-based health checkups from 2010 to 2019 including 19,825 participants. Electrocardiographic LVH was defined according to the Minnesota code. Renal function decline was defined as a decrease of ≥ 25% in the estimated glomerular filtration rate from baseline to < 60 mL/min/1.73 m2. Electrocardiographic LVH was found in 1263 participants at the baseline visit. The mean follow-up period was 3.4 ± 1.9 years. The incidence rates of renal function decline were 0.30 and 0.78 per 100 person-years in the non-LVH group and LVH groups, respectively. Electrocardiographic LVH was associated with the risk for renal function decline in the adjusted analysis (hazard ratio 1.69, 95% confidence interval 1.14–2.50, P = 0.009). This association was comparable across subgroups stratified by age, sex, body mass index, diagnosed hypertension, systolic blood pressure, hemoglobin A1c, and urinary protein. This study underscores the usefulness of electrocardiographic LVH to detect high-risk individuals for renal function decline in the setting of health checkups in the general population.

本文言語英語
論文番号301
ジャーナルScientific reports
14
1
DOI
出版ステータス出版済み - 12月 2024

!!!All Science Journal Classification (ASJC) codes

  • 一般

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