TY - JOUR
T1 - Association between whole blood metallic elements concentrations and gestational diabetes mellitus in Japanese women
T2 - The Japan environment and Children's study
AU - The Japan Environment and Children’s Study Group
AU - Tatsuta, Nozomi
AU - Iwai-Shimada, Miyuki
AU - Nakayama, Shoji F.
AU - Iwama, Noriyuki
AU - Metoki, Hirohito
AU - Arima, Takahiro
AU - Sakurai, Kasumi
AU - Anai, Akane
AU - Asato, Kaname
AU - Kuriyama, Shinichi
AU - Sugawara, Junichi
AU - Suzuki, Kichiya
AU - Yaegashi, Nobuo
AU - Kamijima, Michihiro
AU - Nakai, Kunihiko
N1 - Funding Information:
This study was funded by the Ministry of the Environment, Japan. The funding sources had no role in the study protocol, in the collection, analysis, and interpretation of data, the writing of the report, or in the decision to submit the paper for publication. For this reason, the findings and conclusions of this article are solely the responsibility of the authors and do not represent the official views of the above government agencies.JECS was funded by the Ministry of the Environment, Japan. We would like to thank the participants and Co-operating health care providers for their cooperation in JECS. The authors would like to thank all participants of JECS and all staff members involved in data collection. We would like to acknowledge Drs Taku Obara, and Mami Ishikuro who were the members of Miyagi regional center of JECS. Thank you Dr Yukiko Nishihama for helping me with the statistical analysis. We gratefully acknowledge the contribution of Dr Hiroshi Satoh (Food Safety Commission, Cabinet Office, Tokyo, Japan) and Dr Toshihiro Kawamoto (Japan Industrial Safety and Health Association, Tokyo, Japan) who were former principal investigators of JECS. The findings and conclusions of this article are the sole responsibility of the authors and do not represent the official views of the Japanese government. Members of the Japan Environment and Children's Study (JECS) Group as of 2021. Members of the JECS Group as of 2021: Michihiro Kamijima (principal investigator, Nagoya City University, Nagoya, Japan), Shin Yamazaki (National Institute for Environmental Studies, Tsukuba, Japan), Yukihiro Ohya (National Center for Child Health and Development, Tokyo, Japan), Reiko Kishi (Hokkaido University, Sapporo, Japan), Nobuo Yaegashi (Tohoku University, Sendai, Japan), Koichi Hashimoto (Fukushima Medical University, Fukushima, Japan), Chisato Mori (Chiba University, Chiba, Japan), Shuichi Ito (Yokohama City University, Yokohama, Japan), Zentaro Yamagata (University of Yamanashi, Chuo, Japan), Hidekuni Inadera (University of Toyama, Toyama, Japan), Takeo Nakayama (Kyoto University, Kyoto, Japan), Hiroyasu Iso (Osaka University, Suita, Japan), Masayuki Shima (Hyogo College of Medicine, Nishinomiya, Japan), Youichi Kurozawa (Tottori University, Yonago, Japan), Narufumi Suganuma (Kochi University, Nankoku, Japan), Koichi Kusuhara (University of Occupational and Environmental Health, Kitakyushu, Japan), and Takahiko Katoh (Kumamoto University, Kumamoto, Japan).
Funding Information:
This study was funded by the Ministry of the Environment , Japan. The funding sources had no role in the study protocol, in the collection, analysis, and interpretation of data, the writing of the report, or in the decision to submit the paper for publication. For this reason, the findings and conclusions of this article are solely the responsibility of the authors and do not represent the official views of the above government agencies.
Publisher Copyright:
© 2022 The Authors
PY - 2022/9
Y1 - 2022/9
N2 - Background: Exposure to several metallic elements has been suggested as a risk factor for gestational diabetes mellitus (GDM), but inconsistent findings have been reported. This study aimed to examine the association between the maternal whole blood concentration of metallic elements (Hg, Pb, Cd, Mn, and Se) and GDM using the dataset of the Japan Environment and Children's Study (JECS), a nationwide birth cohort study, which was designed to examine the adverse effects of pre/post-natal exposure to hazardous environment. Methods: The data of 78,964 pregnant women who were participants of JECS were used. Blood samples were collected from the pregnant women at second/third trimester of gestation. We employed logistic regression analysis, quantile g-computation (QGC) and a distributed lag nonlinear model (DLNM) to examine the association between the blood concentration of metallic elements and the risk of GDM. Results: The prevalence of GDM was 2.1%. In the logistic regression analyses, maternal blood Hg was associated with an increased risk of GDM. In QGC analysis, although metallic elements mixtures were not related to an increased risk of GDM, Hg (52.6%) may be the main contributor. According to the results of DLNM, for maternal exposure to Hg, 4.99 ng/g was identified as its susceptible minimum window for elevated risk of GDM. Conclusions: Our findings highlighted an association between Hg exposure and an increased risk of GDM. Studies of the underlying mechanisms and potential contributing factors, including fish intake, of this association are warranted.
AB - Background: Exposure to several metallic elements has been suggested as a risk factor for gestational diabetes mellitus (GDM), but inconsistent findings have been reported. This study aimed to examine the association between the maternal whole blood concentration of metallic elements (Hg, Pb, Cd, Mn, and Se) and GDM using the dataset of the Japan Environment and Children's Study (JECS), a nationwide birth cohort study, which was designed to examine the adverse effects of pre/post-natal exposure to hazardous environment. Methods: The data of 78,964 pregnant women who were participants of JECS were used. Blood samples were collected from the pregnant women at second/third trimester of gestation. We employed logistic regression analysis, quantile g-computation (QGC) and a distributed lag nonlinear model (DLNM) to examine the association between the blood concentration of metallic elements and the risk of GDM. Results: The prevalence of GDM was 2.1%. In the logistic regression analyses, maternal blood Hg was associated with an increased risk of GDM. In QGC analysis, although metallic elements mixtures were not related to an increased risk of GDM, Hg (52.6%) may be the main contributor. According to the results of DLNM, for maternal exposure to Hg, 4.99 ng/g was identified as its susceptible minimum window for elevated risk of GDM. Conclusions: Our findings highlighted an association between Hg exposure and an increased risk of GDM. Studies of the underlying mechanisms and potential contributing factors, including fish intake, of this association are warranted.
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U2 - 10.1016/j.envres.2022.113231
DO - 10.1016/j.envres.2022.113231
M3 - Article
C2 - 35405127
AN - SCOPUS:85128175262
SN - 0013-9351
VL - 212
JO - Environmental Research
JF - Environmental Research
M1 - 113231
ER -
