Association between variants of mast cell chymase gene and serum IgE levels in eczema

X. Q. Mao; T. Shirakawa; T. Enomoto; S. Shimazu; Y. Dake; H. Kitano; A. Hagihara; J. M. Hopkin

doi:10.1159/000022782

Association between variants of mast cell chymase gene and serum IgE levels in eczema

X. Q. Mao
, T. Shirakawa
, T. Enomoto
, S. Shimazu
, Y. Dake
, H. Kitano
, A. Hagihara
, J. M. Hopkin

医療経営・管理学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

42 被引用数 (Scopus)

抄録

851 school children aged at 12-13 years including 145 with eczema were tested for genetic association to a mast cell chymase (MCC) genetic variant. MCC genotypes showed a strong association with eczema, but not with asthma and rhinitis. This association is strongest in eczematous children with lower serum total IgE levels. Independent of IgE responsiveness when total serum IgE of less than 500 IU/ml, MCC variants may play an important role in inflammatory skin disorders.

本文言語	英語
ページ（範囲）	38-41
ページ数	4
ジャーナル	Human Heredity
巻	48
号	1
DOI	https://doi.org/10.1159/000022782
出版ステータス	出版済み - 1月 1998

!!!All Science Journal Classification (ASJC) codes

遺伝学
遺伝学（臨床）

文献へのアクセス

10.1159/000022782

他のファイルとリンク

引用スタイル

@article{680408d9b3e94990928ec009a25a6584,

title = "Association between variants of mast cell chymase gene and serum IgE levels in eczema",

abstract = "851 school children aged at 12-13 years including 145 with eczema were tested for genetic association to a mast cell chymase (MCC) genetic variant. MCC genotypes showed a strong association with eczema, but not with asthma and rhinitis. This association is strongest in eczematous children with lower serum total IgE levels. Independent of IgE responsiveness when total serum IgE of less than 500 IU/ml, MCC variants may play an important role in inflammatory skin disorders.",

author = "Mao, \{X. Q.\} and T. Shirakawa and T. Enomoto and S. Shimazu and Y. Dake and H. Kitano and A. Hagihara and Hopkin, \{J. M.\}",

year = "1998",

month = jan,

doi = "10.1159/000022782",

language = "English",

volume = "48",

pages = "38--41",

journal = "Human Heredity",

issn = "0001-5652",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Association between variants of mast cell chymase gene and serum IgE levels in eczema

AU - Mao, X. Q.

AU - Shirakawa, T.

AU - Enomoto, T.

AU - Shimazu, S.

AU - Dake, Y.

AU - Kitano, H.

AU - Hagihara, A.

AU - Hopkin, J. M.

PY - 1998/1

Y1 - 1998/1

N2 - 851 school children aged at 12-13 years including 145 with eczema were tested for genetic association to a mast cell chymase (MCC) genetic variant. MCC genotypes showed a strong association with eczema, but not with asthma and rhinitis. This association is strongest in eczematous children with lower serum total IgE levels. Independent of IgE responsiveness when total serum IgE of less than 500 IU/ml, MCC variants may play an important role in inflammatory skin disorders.

AB - 851 school children aged at 12-13 years including 145 with eczema were tested for genetic association to a mast cell chymase (MCC) genetic variant. MCC genotypes showed a strong association with eczema, but not with asthma and rhinitis. This association is strongest in eczematous children with lower serum total IgE levels. Independent of IgE responsiveness when total serum IgE of less than 500 IU/ml, MCC variants may play an important role in inflammatory skin disorders.

UR - https://www.scopus.com/pages/publications/0031962264

UR - https://www.scopus.com/pages/publications/0031962264#tab=citedBy

U2 - 10.1159/000022782

DO - 10.1159/000022782

M3 - Article

C2 - 9463800

AN - SCOPUS:0031962264

SN - 0001-5652

VL - 48

SP - 38

EP - 41

JO - Human Heredity

JF - Human Heredity

IS - 1

ER -

Association between variants of mast cell chymase gene and serum IgE levels in eczema

抄録

!!!All Science Journal Classification (ASJC) codes

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル