Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma

Tomomitsu Hirota, Kazuhiko Obara, Akira Matsuda, Mitsuteru Akahoshi, Kazuko Nakashima, Koichi Hasegawa, Naomi Takahashi, Makiko Shimizu, Hiroshi Sekiguchi, Miki Kokubo, Satoru Doi, Hiroshi Fujiwara, Akihiko Miyatake, Kimie Fujita, Tadao Enomoto, Fumio Kishi, Yoichi Suzuki, Hirohisa Saito, Yusuke Nakamura, Taro ShirakawaMayumi Tamari

研究成果: ジャーナルへの寄稿学術誌査読

11 被引用数 (Scopus)


Lung epithelium plays a central role in modulation of the lung inflammatory response, and lung repair and airway epithelial cells are targets in asthma and viral infection. Activated T lymphocytes release cytokines such as interferon-gamma (IFN-γ) that induce apoptosis, or programmed cell death, of damaged epithelial cells. Death-associated protein-3 (DAP3) is involved in mediating IFN-γ-induced cell death. To assess the possible involvement of genetic variants of DAP3 with asthma, we searched for single-nucleotide polymorphisms (SNPs) in the gene and conducted a case-control study with 1,341 subjects. We found a strong association between bronchial asthma (BA) in adults (P = 0.0051, odds ratio = 1.87, 95% CI= 1.20-2.92), whereas no association was found with childhood asthma. The tendency was more prominent in patients with higher serum total immunoglobulin E (IgE) (>250IU/ml) (P = 0.00061, odds ratio = 2.40, 95% CI= 1.44-4.00). DAP3 was expressed in normal bronchial epithelial cells, and the expression was induced by IFN-γ. These results indicated that specific variants of the DAP3 gene might be associated with the mechanisms responsible for adult BA and contribute to airway inflammation and remodeling.

ジャーナルJournal of Human Genetics
出版ステータス出版済み - 2004

!!!All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 遺伝学(臨床)


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